Endocrinology 11 Flashcards

1
Q

What syndrome do you get from too much Aldosterone?

A

Conn’s syndrome

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2
Q

What syndrome do you get with too little aldosterone?

A

Addisons disease

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3
Q

What disease do you get with too much cortisol?

A

Cushing’s disease

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4
Q

What condition do you get with too little cortisol?

A

Addisons disease

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5
Q

What does too much aldosterone cause?

A
  • Increase in ECF
  • Increase in BP
  • Hypokalemia (potassium deficiency)
  • Metabolic alkalosis
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6
Q

What does too little aldosterone cause (Addison’s disease)

A
  • Hypotension
  • Metabolic acidosis
  • Hyperkalemia
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7
Q

What does too much cortisol cause in cushing’s disease?

A
  • Increase blood glucose
  • Muscle wasting
  • Moon face
  • Buffalo hump
  • Increased resistance to infection
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8
Q

What does too little cortisol cause in Addison’s disease?

A
  • Decreased blood glucose

* Increase skin pigmentation

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9
Q

What is Virilization?

A

Acondition in which a female develops characteristics associated with male hormones (androgens)

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10
Q

What does too much androgens cause?

A

Virilization

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11
Q

What does too little androgens cause?

A

A decrease in sexual hair growth and a decrease in libido

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12
Q

What does the adrenal medulla synthesize?

A

Catechoamines

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13
Q

What is the precursor molecule to Catecholamines?

A

Tyrosin

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14
Q

What is the order of Tyrosine all the way to adrenaline?

A
  • Tyrosine
  • Dopa
  • Dopamine
  • Noradrenaline
  • Adrenaline
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15
Q

How do Adrenaline and Noradrenaline affect the cardiovascular system?

A
  • Increase heart rate
  • Increase force of contraction
  • Increase cardiac output
  • Increase blood pressure
  • Redistribute blood flow
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16
Q

How do Adrenal and Noradrenaline affect smooth muscle?

A
  • Dilation of pupils
  • Bronchodilation
  • Decrease in GIT motility
17
Q

How do Adrenaline and Noradrenaline affect metabolism?

A
  • They increase Glycogenolysis (skeletal muscle and liver)
  • They increase Lipolysis
  • Increase gluconeogenesis
18
Q

What is the adrenal portion of the adrenal medulla innervated by?

A

The Splanchnic nerve

19
Q

What kind of nerve is the Splanchnic nerve?

A

It is a sympathetic preganglionic nerve

20
Q

What are the sympathetic postganglionic fibers that the Splanchnic nerve would have equivalent to?

A

The chromaffin cells in the adrenal medulla

21
Q

What kind of cells are located in the adrenal medulla?

A

Chromaffin cells

22
Q

What are Chromaffin cells the site of production for?

A

Noradrenaline and Adrenaline

23
Q

What are chromaffin cells the site of production for?

A

Adrenaline and noradrenaline

24
Q

What are chromaffin cells in the adrenal medulla innervated by?

A

The Splanchnic nerve

25
Q

What neurotransmitter stimulates chromaffin cells?

A

Acetylcholine

26
Q

Why is noradrenaline both a neurotransmitter and hormone?

A

Because it can be released from chromaffin cells or it can be released from sympathetic postganglionic fibres