Hyperuricemia and Gout - Chapter 17 Flashcards
1
Q
Hyperuricemia
A
-A condition in which urate (uric acid) levels build up in the blood stream
2
Q
Gout
A
-The primary disease associated with Hyperuricemia
3
Q
Pathophysiology of Gout
A
- Hyperuricemia causes urate crystals to be deposited in joints, producing inflammation and pain
- “Disease of Kings” or “Rich Man’s Disease”
4
Q
Drugs Used to Treat or Prevent Gout or Hyperuricemia
A
- Analgesics
- Antiinflammatories
- Uricosurics
- Inhibitors or uric acid synthesis
- Uric acid metabolizer (for hyperuricemia due to chemotherapy)
5
Q
Analgesics and Antiinflammatory Drugs Examples
A
- colchicine
- NSAIDS
- Glucocorticosteroids
6
Q
Colchicine
A
- Use limited to gout
- For gout flare; must start within 36 hours to be effective
7
Q
Colchicine ADR’s
A
- n/v
- Bone marrow depression
- Neuropathy
- Muscle damage
- Multiple organ failure
- Death
8
Q
Colchicine Warning Labels
A
- AVOID ALCOHOL
- AVOID GRAPEFRUIT
- TAKE WITH LOTS OF WATER
9
Q
NSAIDS Used for Gout
A
-Most commonly prescribed is indomethacin, but any NSAID may be used
10
Q
Brand: Indocid
A
Generic: indomethacin
11
Q
Glucocorticosteroids for Gout
A
- Oral glucocorticosteroids such as prednisone, dexamethasone, or hydrocortisone may be used
- Intraarticular injections may be given when only 1 or 2 joints are affected
12
Q
Glucocorticosteroids for Gout Examples
A
- methylprednisolone
- triamcinolone
13
Q
Brand: Medrol, Depo-Medrol, Solu-Medrol
A
Generic: methylprednisolone
14
Q
Brand: Kenalog
A
Generic: triamcinolone
15
Q
Uricosurics
A
- Increase the clearance of uric acid by inhibiting the reabsorption of uric acid in the renal tubules and promoting the renal elimination or urates
- PREVENTATIVE ONLY (Not for treatment)
