Final Exam Flashcards - Autoimmune Diseases

Question 1

Autoimmune disease

Answer 1

-Occurs when the immune system turns against itself

Question 2

Myasthenia Gravis

Answer 2

-Causes weakness of the skeletal muscles of face, neck, and limbs and fatigue after brief activity

Question 3

Myositis

Answer 3

-Chronic inflammation of muscles

Question 4

Multiple Sclerosis

Answer 4

-Myelin is attacked causing inflammation and often permanently damaging the myelin. Nerve impulses may be completely disrupted

Question 5

Rheumatoid Arthritis

Answer 5

-Inflammation of the lining of the joints

Question 6

Drugs Used to Suppress Inflammation and Reduce Swelling

Answer 6

• Glucocorticosteroids
• NSAIDS
• Salicylates

Question 7

Drugs That slow the Progression of the Disease

Answer 7

• DMARDs

- BRM’s

Question 8

Glucocorticosteroids

Answer 8

-Inhibit synthesis of proinflammatory substances and antibodies responsible for attacking healthy cells

Question 9

Glucocorticosteroids ADR’s

Answer 9

• GI ulceration
• Osteoporosis
• Hypertension
• Cataracts
• Poor wound healing
• Infection
• Moon face, buffalo hump

Question 10

NSAIDs

Answer 10

-Used for treatment of pain and inflammation

Question 11

NSAIDs ADR’s

Answer 11

• Hepatotoxicity (ketorolac)
• Salicylism (aspirin)
• Agranulocytosis (indomethacin, flurbiprofen)
• Nausea
• GI bleeding
• Ulceration
• Dizziness

Question 12

DMARDs

Answer 12

-Slow the progression of disease

Include:

• Immunosuppressants
• Antimalarials
• Interleukin antagonists
• Fusion Protein
• TNFa inhibitors
• BRM’s that are not TNFa inhibitors

Question 13

Immunosuppressants

Answer 13

-Suppress the immune system by damaging RNA and DNA needed for cell replication

Question 14

DMARDs: Antimalarials

Answer 14

• For RA and SLE

- Have antiinflammatory and analgesic properties

Question 15

Additional DMARDs for RA

Answer 15

• leflunomide
• sulfasalazine
• auranofin
• penicillamine

Question 16

Leflunomide ADR’s

Answer 16

• Liver toxicity
• Fetal toxicity
• Liver dysfunction
• Nausea
• Hair loss

Question 17

Sulfasalazine ADR’s

Answer 17

• Damage to WBC
• GI upset
• Photosensitivity
• Crystalluria
• Impaired folic acid absorption

Question 18

Gold Compounds ADR’s

Answer 18

• Itching
• Rash
• Metallic taste
• Photosensitivity
• Proteinuria
• interstitial pneumonia

Question 19

Pencillamine ADR’s

Answer 19

• Rash
• GI upset
• Nephrotoxicity

Question 20

BRM’s

Answer 20

• inhibit the release of cells that mobilize to fight a what the body believes is a harmful invasion
• Inhibit release of substances that produce inflammation

Question 21

Interleukin Antagonists

Answer 21

-Interferes with binding of interleukins that produce inflammatory response

Question 22

TNFa Inhibitors

Answer 22

-Block the inflammatory process

Question 23

Myasthenia Gravis

Answer 23

-Cholinesterase inhibitors block the destruction of ACh at neuromuscular junctions