Final Exam Flashcards - GERD & Peptic Ulcer Disease

Question 1

GERD

Answer 1

• A motility disorder associated with impaired peristalsis
• Causes backflow of gastric contents into the esophagus
• May cause heartburn, inflammation and ulceration, esophageal cancer, and may increase risk of development of chronic diseases such as asthma

Question 2

Peptic Ulcer Disease (PUD)

Answer 2

• An ulcer is an open wound or sore
• A peptic ulcer is an ulcer in the stomach or duodenum
• An ulcer located in the stomach is a gastric ulcer
• An ulcer in the upper region of the small intestine is a duodenal ulcer

Question 3

Treatment Strategies for PUD and GERD

Answer 3

1) Reduce GI irritants
2) Increase protective factors
3) Eliminate H. Pylori (PUD)
4) Enhance peristalsis (GERD)

Question 4

Drug Classifications for Treatment of GERD and PUD

Answer 4

• Antacids
• Acid suppressing drugs (histamine antagonists, proton pump inhibitors)
• Mucosal protectants
• Antiinfectives
• Prokinetic Drugs

Question 5

Antacids

Answer 5

• Oldest drugs used for GERD and PUD

- Neutralize gastric acids

Question 6

Acid Suppressing Drugs: Histamine2 Antagonists

Answer 6

• Common ending: “tidine”

- Block histamine stimulated acid secretion

Question 7

Histamine2 Receptor Antagonists ADR’s

Answer 7

• Gynecomastia-cimetidine
• Dizziness
• Headache
• Constipation/diarrhea
• Nausea
• Abdominal pain
• Bloating

Question 8

Acid Suppressing Drugs: Proton Pump Inhibitors

Answer 8

• Common ending: “prazole”
• Interfere with final step in gastric acid production and decrease gastric acids
• More potent than H2 receptor antagonists

Question 9

Proton Pump Inhibitors ADR’s

Answer 9

• Vitamin B deficiency
• Rebound hyperacidity
• Abdominal pain
• Diarrhea/constipation
• Headache
• Skin rash
• Agitation

Question 10

Mucosal Protectants

Answer 10

-Protect cells that line the stomach and small intestine form damage by gastric acids

Question 11

Misoprostol ADR’s

Answer 11

• Miscarriage
• Abdominal cramps
• Diarrhea
• Menstrual irregularities
• Headache
• Dizziness

Question 12

Sucralfate ADR’s

Answer 12

• Constipation
• Headache
• Gas
• Dry mouth

Question 13

Misoprostol Tech Note!

Answer 13

-Contraindicated in pregnancy

Question 14

Antiinfectives

Answer 14

-Antibacterials to eradicate H. Pylori infection

Question 15

Prokinetic Drugs

Answer 15

-Increase peristalsis, GI motility, gastric emptying, and improve sphincter tone

Question 16

Prokinetic Drugs ADR’s

Answer 16

• Gynecomastia (domperidone)
• Abdominal pain
• Constipation
• Restlessness
• Dizziness
• Headache
• Irregular heartbeat