Final Exam Flashcards - Neuromuscular Blockade

Question 1

Neuromuscular Blocking Agents

Answer 1

-Interfere with transmission at the neuromuscular endplate and are primarily used as adjucts during general anesthesia to paralyze the patient so they don’t move during surgery

Question 2

Neuromuscular Blockade MOA

Answer 2

• Increase inactive ACh nicotinic receptor sites
• Decreasing ACh release
• Depleting neuronal ACh

Question 3

Muscle Relaxants MOA

Answer 3

-NMBA’s increase the percent of ACh receptor sites that are inactivated, causing skeletal muscle relaxation

Question 4

Peripheral Acting Skeletal Muscle Relaxants/NMBAs

Answer 4

Classified as:

• Depolarizing
• Nondepolarizing

Question 5

Depolarizing NMBA’s

Answer 5

• Bind to ACh receptors and produce sustained depolarization, causing receptors to convert to their inactive state
• Inactivated by cholinesterase enzymes

Question 6

Nondepolarizing NMBA’s

Answer 6

• Common ending: “curium” & “curonium”
• Competitive antagonists
• Interfere with NA+, Ca++, and K+ channels and decrease acetylcholinesterase action

Question 7

NMBA’s ADR’s

Answer 7

• Respiratory depression
• Cardiac arrest
• Muscle pain
• Pulmonary edema
• Allergic reactions
• Tachycardia or bradycardia

Question 8

Reversal of Neuromuscular Blockade

Answer 8

-Anticholinesterase drugs inhibit the action of ACh esterase at the neuromuscular junction

Question 9

Anticholinesterase Drugs ADR’s

Answer 9

• Salivation
• Muscle twitching
• Muscle weakness
• Abdominal cramping
• Nausea
• Difficulty breathing