Final Exam Flashcards - Gout
1
Q
Urates
A
-The product of the metabolism of purine
2
Q
Hyperueicemia
A
-Condition in which uric acid levels build up in the blood serum
3
Q
Gout
A
-The primary disease associated with hyperuricemia
4
Q
Drugs Used to Treat and/or Prevent Gout/Hyperuricemia
A
- Analgesics
- Anti-Inflammatories
- Uricosurics
- Inhibitors or uric acid synthesis
- Uric acid metabolizer
5
Q
Analgesics and Anti-Inflammatories
A
- Colchicine
- NSAIDS
- Glucocorticosteroids
6
Q
Colchicine
A
- Penetrates inflammatory cells and inhibits their ability to travel to the site of irritation
- Use limited to gout
- For gout flare; must start within 36 hours
7
Q
Colchicine ADR’s
A
- Bone marrow suppression
- Neuropathy
- Multiple organ failure
- Death
8
Q
NSAIDS for Gout
A
-Most common is indomethacin, but others can be used
9
Q
Uricosurics
A
- Increase the clearance of uric acid by inhibiting the reabsorption of uric acid in the renal tubules and promoting the renal elimination of urates
- PREVENTATIVE ONLY
10
Q
Uricosurics ADR’s
A
- N/V
- Worsening of kidney stones
11
Q
Inhibitors of Uric Acid Synthesis (Xanthine Oxidase Inhibitors)
A
-Block final step in uric acid synthesis
12
Q
Allopurinol ADR’s
A
- Nausea
- Drowsiness
- Headache
- Diarrhea
- Itchy skin rash
13
Q
Febuxostat ADR’s
A
- gout flare up
- N/V
- Appetite changes
- MI/Stroke
- Atrial fibrillation
- Rhabdomyolysis
14
Q
Uric Acid Metabolizer
A
- For hyperuricemia induced by chemotherapy
- Metabolizes uric acid to allantoin
