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Pharmacology and Therapeutic Terminology > Autoimmune Diseases That Affect the Musculoskeletal System - Chapter 15 > Flashcards

Autoimmune Diseases That Affect the Musculoskeletal System - Chapter 15 Flashcards

1
Q

Autoimmune Diseases

A

-occurs when the immune system turns against itself

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2
Q

Autoimmune Disease Triggers

A
  • Virus exposure
  • Environmental toxins
  • Sun
  • Genetics
  • Hormonal changes
  • Drugs
  • Pregnancy
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3
Q

Myositis

A

-Chronic inflammation of muscles

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4
Q

Multiple Sclerosis

A
  • Myelin is attacked causing inflammation and often permanent damage
  • Nerve impulses can be completely disrupted
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5
Q

Symptoms of MS

A
  • Vision and speech disturbances
  • Extreme fatigue
  • Bladder and bowel dysfunction
  • Spasticity and tremor
  • Pain
  • Depression/mood changes
  • Balance problems
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6
Q

Rheumatoid Arthritis

A

-Characterized by inflammation of the lining of the joints, pain, joint damage, and disability

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7
Q

Systemic Lupus Erythematosus

A
  • ANA levels are elevated

- Has many different symptoms. called “the disease with 1000 faces”

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8
Q

Treatment of Autoimmune Diseases that Affect the Musculoskeletal System

A
  • Suppress inflammation and reduce swelling and pain

- Slow progression of disease

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9
Q

Drugs That Suppress Inflammation ands Reduce Swelling and Pain

A
  • Glucocorticosteroids
  • NSAIDS
  • Salicylates
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10
Q

Drugs that Slow Progression of Disease

A
  • DMARDS

- BRM’s

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11
Q

Glucocorticosteroids Examples

A
  • betamethasone
  • dexamethasone
  • hydrocortisone
  • methylprednisolone
  • prednisone
  • prednisolone
  • triamcinolone
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12
Q

Brand: Betaject, Celestone Soluspan

A

Generic: betamethasone acetate

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13
Q

Brand: Decadron, Dexasone

A

Generic: dexamethasone

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14
Q

Brand: Cortef, Solu-Cortef

A

Generic: hydrocortisone

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15
Q

Brand: Depo-Medrol, Medrol, Solu-Medrol

A

Generic: methylprednisolone

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16
Q

Brand: Winpred, Deltasone

A

Generic: prednisone

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17
Q

Brand: Pediapred

A

Generic: prednisolone

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18
Q

Brand: Aristospan, Kenalog-10, Kenalog-40

A

Generic: triamcinolone

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19
Q

Glucocorticosteroids ADR’s

A
  • Gi ulceration
  • Osteoporosis
  • Acne
  • Cataracts
  • Poor wound healing
  • Infection
  • Insomnia
  • Euphoria
  • Edema
  • Hypertension
  • Nausea
  • Weight gain
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20
Q

Glucocorticosteroid Warning Labels

A
  • TAKE WITH FOOD
  • DONT D/C ABRUPTLY
  • TAKE AT THE SAME TIME EACH DAY
  • TAKE WITH FULL GLASS OF WATER
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21
Q

NSAIDS and Aspirin (ASA) Examples

A
  • acetylsalicylic acid
  • celecoxib
  • diclofenac
  • diclofenac/misoprostol
  • diflunisal
  • etodolac
  • floctafenine
  • flurbiprofen
  • ibuprofen
  • indomethacin
  • ketoprofen
  • ketorolac
  • mefenamic acid
  • meloxicam
  • nabumetone
  • naproxen
  • naproxen sodium
  • oxaprozin
  • piroxicam
  • sulindac
  • tenoxicam
  • tiaprofenic acid
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22
Q

Brand: Aspirin

A

Generic: acetylsalicylic acid

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23
Q

Brand: Celebrex

A

Generic: celecoxib

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24
Q

Brand: Voltaren, Voltaren SR, Voltarin Rapide, voltaren Emugel, Cambia, Pennsaid

A

Generic: diclofenac

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25
Q

Brand: Arthrotec

A

Generic: diclofenac/misoprostol

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26
Q

Brand: diflunisal, Dolobid

A

Generic: diflunisal

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27
Q

Brand: etodolac, Ultradol

A

Generic: etodolac

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28
Q

Brand: floctafenine, Idarac

A

Generic: floctafenine

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29
Q

Brand: flurbiprofen, Ansaid, Froben

A

Generic: flubiprofen

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30
Q

Brand: Advil, Motrin

A

Generic: ibuprofen

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31
Q

Brand: indomethacin, Indocid

A

Generic: indomethacin

32
Q

Brand: ketoprofen, Orudis SR

A

Generic: ketoprofen

33
Q

Brand: Toradol

A

Generic: ketorolac

34
Q

Brand: mefenamic acid, Ponstan

A

Generic: mefenamic acid

35
Q

Brand: Mobicox

A

Generic: meloxicam

36
Q

Brand: nabumetone, Relafen

A

Generic: nabumetone

37
Q

Brand: Naprosyn, Naprosyn SR, Naprelan

A

Generic: naproxen

38
Q

Brand: Aleve, Anaprox, Anaprox DS

A

Generic: naproxen sodium

39
Q

Brand: oxaprozin, Daypro

A

Generic: oxaprozin

40
Q

Brand: piroxicam, Feldene

A

Generic: piroxicam

41
Q

Brand: sulindac, Clinoril

A

Generic: sulindac

42
Q

Brand: tenoxicam, Mobiflex

A

Generic: tenoxicam

43
Q

Brand: tiaprofenic acid, Surgam

A

Generic: tiaprofenic acid

44
Q

NSAIDS and ASA ADR’s

A
  • Nausea
  • GI bleeding
  • Ulceration
  • Dizziness
  • Salicylism (aspirin)
  • Hepatotoxicity (ketoralac)
45
Q

NSAID Warning Labels

A
  • TAKE WITH FOOD
  • AVOID ASPIRIN AND RELATED PRODUCTS
  • MAY CAUSE DIZZINESS
  • SWALLOW WHOLE; DONT CRUSH OR CHEW
46
Q

Different Types of Disease-Modifying Antirheumatic Drugs (DMARDS)

A
  • Immunosuppressives
  • Antimalarials
  • Interleukin antagonists (BRM)
  • Fusion Protein (BRM)
  • TNFa inhibitors (BRM)
  • Non TNF-a Inhibitors
47
Q

Immunosuppressants Examples

A
  • azathioprine
  • cyclophosphamide
  • cyclosporine
  • chlorambucil
  • methotrexate
  • tacrolimus
48
Q

Brand: Imuran

A

Generic: azathioprine

49
Q

Brand: Cytoxan, Procytox

A

Generic: cyclophosphamide

50
Q

Brand: Neoral, Sandimune I.V.

A

Generic: cyclosporine

51
Q

Brand: Leukeran

A

Generic: chlorambucil

52
Q

Brand: Rheumatrex

A

Generic: methotrexate

53
Q

Brand: Prograf

A

Generic: tacrolimus

54
Q

Immunosuppressant Warning Labels

A
  • TAKE WITH FOOD
  • AVOID PREGNANCY
  • TAKE AT THE SAME TIME EACH DAY
  • SWALLOW WHOLE; DONT CRUSH OR CHEW
  • AVOID ASPIRIN AND NSAIDS (cyclophosphamide)
  • AVOID ALCOHOL (cyclosporine)
  • AVOID GRAPEFRUIT JUICE (cyclosporine)
55
Q

Methotrexate Warning Labels

A
  • AVOID ASA AND NSAIDS
  • AVOID ALCOHOL
  • AVOID PROLONGUE EXPOSURE TO SUNLIGHT
  • AVOID PREGNANCY
56
Q

Antimalarials Examples

A
  • chloroquine

- hydroxychloroquine

57
Q

Brand: chloroquine, Aralen

A

Generic: chloroquine

58
Q

Brand: Plaquenil

A

Generic: hydroxychloroquine

59
Q

Antimalarial Warning Labels

A
  • AVOID ANTACIDS
  • TAKE WITH FOOD
  • AVOID PROLONGUED EXPOSURE TO SUNLIGHT
60
Q

Additional DMARDS for RA Examples

A
  • leflunomide
  • sulfasalazine
  • auranofin
  • penicillamine
61
Q

Brand: Arava

A

Generic: leflunomide

ADRs:

  • liver toxicity
  • fetal toxicity
  • nausea
  • hair loss
  • liver disfunction
62
Q

Brand: Salazopyrin

A

Generic: sulfasalazine

ADR’s:

  • GI upset
  • photosensitivity
  • allergy
  • crystalluria
  • impaired folic acid absorption
  • damage to white blood cells
63
Q

Brand: Ridaura

A

Generic: auranofin

ADR’s: itching

  • rash
  • metallic taste
  • photosensitivity
  • sore mouth
  • interstitial pneumonia
64
Q

Brand: Cuprimine

A

Generic: penicillamine

ADR’s:

  • rash
  • GI upset
  • nephrotoxicity
65
Q

Biological Response Modifiers (BRM): Interleukin Antagonists Examples

A

-anakinra

66
Q

Brand: Kineret

A

Generic: anakinra

67
Q

Biological Response Modifiers (BRM): TNF-a Inhibitors Examples

A
  • adalimumab
  • infliximab
  • certolizumab
  • golimumab
  • etanercept
68
Q

Brand: Humira

A

Generic: adalimumab

69
Q

Brand: Remicade, Remsima, Inflectra

A

Generic: infliximab

70
Q

Brand: Cimzia

A

Generic: certolizumab

71
Q

Brand: Simponi

A

Generic: golimumab

72
Q

Brand: Enbrel

A

Generic: etanercept

73
Q

Other DMARDS

A
  • minocycline

- sodium aurothiomalate

74
Q

Brand: Minocin

A

Generic: minocycline

75
Q

Brand: Myochrisine, Sodium Aurothiomalate Inj.

A

Generic: sodium aurothiomalate

Pharmacology and Therapeutic Terminology (97 decks)

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