Allergies - Chapter 24 Flashcards
Allergy
-A hypersensitivity reaction by the immune system upon exposure to an allergen
Allergen
-A type of antigen that produces an immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body
Common Allergies
- Pollen
- Dust mites
- Molds
- Animal dander
- Insect bites
- Latex
- Foods
- Drugs
Mechanism of Allergic Response
- Exposure to allergen
- Immune system treats allergen as an invader and activates B cells to produce antibodies to the allergen
- Release of inflammatory substances causes the symptoms of the allergic reaction
Allergic Rhinitis
-Symptoms are caused by inflammation of the nasal passageways causing itching, sneezing, runny nose, etc.
Allergic
Conjunctivitis
-Inflammation of the eyes causing red, puffy, watering, itchy, and/or burning eyes
Urticaria
- Hives
- Caused by insect bites, drugs, foods, etc.
Anaphylaxis
- A life threatening allergic reaction
- Most dangerous symptoms are: impaired breathing and an extreme drop in blood pressure causing dizziness, fainting, etc.
Anaphylaxis Treatment
-epinephrine im, iv, or sc
Generic: epinephrine
Adrenalin
EpiPen
Allerject
Drug Treatment of Allergies
- Reduce inflammation and supress release of cells that mediate immune and inflammatory responses
- Block receptor sites of mediators
- Symptom relief
Classifications of Drugs Used to Treat Allergies
- Antihistamines
- Intranasal corticosteroids
- Oral or iv corticosteroids
- Mast cell stabilizers
- Leukotrine receptor antagonists
- Immunotherapy
- Vasoconstrictors
- Topical corticosteroids
Antihistamines
-Prevent binding at H1 receptor sites by competing with free histamine
First Generation/Non-Selective/Classical Antihistamines Examples
- diphenhydramine
- brompheniramine
- chlorpheniramine
- hydroxyzine
- trimeprazine
Generic: diphenhydramine
Benadryl
- First generation/non-selective/classical antihistamine
- OTC
Generic: brompheniramine
Combination products for allergy and cold
- First generation/non-selective/classical antihistamine
- OTC
Generic: chlorpheniramine
Chlorpheniramine
- First generation/non-selective/classical antihistamine
- OTC
Generic: hydroxyzine
Atarax
- First generation/non-selective/classical antihistamine
- RX
Generic: trimeprazine
Panectyl
- First generation/non-selective/classical antihistamine
- RX
-First Generation/Non-Selective/Classical Antihistamines ADR’s
- Sedation
- Possible thickening of mucus
- Dry mouth
- Pupil dilation
- Urinary retention
First Generation Antihistamines Warning Labels
- MAY CAUSE DROWSINESS
- MAY CAUSE DIZZINESS
Second Generation (Selective) Antihistamines
-More selective for H1 receptors, no anticholinergic action, and generally do not cross BBB
Second Generation Antihistamines Examples
- cetirizine
- ketotifen
- loratidine
- desloratidine
- fexofenadine