Final Exam Flashcards - Prostate Disease & ED
1
Q
Benign Prostatic Hyperplasia (BPH)
A
-Non-cancerous condition that increases the size of the prostate gland which obstructs urine flow
2
Q
BPH Pharmacological Treatment
A
- a1 Blockers
- 5a-reductase inhibitors
- Combination of the above
3
Q
A1 Blockers
A
- common ending: “osin”
- Bind to a1 receptor sites
- Relax the prostate and bladder smooth muscle and improve flow of urine
4
Q
A1-Adrenergic Antagonists ADR’s
A
- Postural Hypotension
- Reflex tachycardia
- Dizziness
- Headache
- Fatigue
- Weakness
- Nasal stuffiness
5
Q
5a- Reductase Inhibitors
A
- Common ending: “steride”
- Inhibit 5a-Reductase
6
Q
5a-Reductase Inhibitors ADR’s
A
- Erectile disfunction
- Decreased desire for sex
- Reduced semen
7
Q
Finasteride Tech Note!
A
-Finasteride 1 mg is prescribed for male pattern baldness
8
Q
Erectile Dysfunction
A
-The total or inconsistent inability to achieve erection, or difficulty maintaining erection
9
Q
Pharmacological Treatment of ED
A
- PDE5 inhibitors
- Prostaglandins
10
Q
PDE5 Inhibitors
A
- Common ending: “afil”
- Require sexual stimulation for effect
- When PDE5 is inhibited, the vasodilatory effect of nitric oxide is enhanced causing relaxation of smooth muscle and blood vessels or the corpus cavernosum, enabling an erection
11
Q
PDE5 Inhibitors ADR’s
A
- Sudden hearing loss
- Prolonged erection
- Visual disturbances
- Dizziness
- Headache
- Flushing
- Diarrhea
12
Q
PDE5 Inhibitors Tech Note!
A
- Nitrates are contraindicated while taking PDE5 inhibitors
- A-adrenergic antagonists are to be used with caution due to risk of low blood pressure
13
Q
Prostaglandins
A
-aloprostadil
