Final Exam Flashcards - Psychology

1
Q

4 Major Types of Anxiety Disorders

A
  • Generalized anxiety disorder (GAD)
  • Panic disorder
  • Obsessive Compulsive Disorder (OCD)
  • Post Traumatic Stress Disorder (PTSD)
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2
Q

Pharmaceutical Treatment of Anxiety Disorders

A

Drugs that affect the neurotransmitters:

  • Y-aminobutyric acid (GABA)
  • Serotonin (5-HT)
  • Norepinephrine (NE)
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3
Q

Benzodiazepines

A
  • Enhance binding of GABA
  • Have a high degree of lipid solubility
  • Common ending: “epam” & “olam”
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4
Q

3 Primary Types of Depression

A
  • Major depression
  • Bipolar Disorder
  • Dysthymia
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5
Q

Major Depression

A
  • AKA clinical depression
  • Persistent feelings of sadness, emptiness, or hopelessness usually accompanied by fatigue, lack of interest, irritability, insomnia or hypersomnia, etc.
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6
Q

Bipolar Disorder

A
  • AKA manic depressive disorder

- Associated with mood swings between depression and periods of mania

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7
Q

Dysthymia

A

-Produces symptoms that are similar to major depression; however, they are less severe

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8
Q

Biogenic Amine Theory

A
  • Clinical depression results from a decrease in monoamine neurotransmitters in the brain, especially NE, Dopamine, and serotonin.
  • In bipolar disorder, the manic phase is believed to be associated with increased levels of monoamine neurotransmitters
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9
Q

Tricyclic Antidepressants

A

-Block the reuptake of NE and 5-HT

ADR’s: Photosensitivity and cardiotoxicity

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10
Q

ADR’s Related to Blockade of Histaminic Receptors

A
  • Sedation
  • Weight gain
  • Hypotension
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11
Q

ADR’s Related to Blockade of Muscarinic Receptors

A
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
  • Confusion
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12
Q

Selective Serotonin Reuptake Inhibitors (SSRI’s)

A
  • Selectively inhibit the reuptake of serotonin at the synaptic cleft
  • Most widely prescribed antidepressants
  • Equally effective as TCA’s, yet lack cardiotoxic effects
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13
Q

SSRI’s ADR’s

A
  • Decreased appetite
  • Nausea
  • Agitation or anxiety
  • Diarrhea
  • Sexual dysfunction
  • Suicide ideation
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14
Q

Serotonin-Norepinephrine Reuptake inhibitors

A

-Inhibit the reuptake of 5-HT and NE

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15
Q

SNRI ADR’s

A
  • Sedation
  • Dizziness
  • Nausea
  • Insomnia
  • Dry mouth
  • Increased BP
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16
Q

Norepinephrine Dopamine Reuptake Inhibitor (NDRI)

A

-Alternative to TCA’s; do not cause drowsiness

17
Q

NDRI ADR’s

A
  • Insomnia
  • Headache
  • Aggression
  • Dry mouth
  • Seizures
18
Q

Drugs Used to Treat Bipolar Disorder

A
  • Have anti-manic actions
  • Lithium is the oldest
  • Some drugs used for schizophrenia are also used for bipolar disorder
19
Q

Lithium

A
  • Used to reduce current symptoms of mania and depression
  • Very Narrow TI drug
  • Has long T1/2 which can double over the course of a year’s continuous therapy
20
Q

Bipolar Drugs ADR’s

A
  • Sedation or dizziness
  • Nausea
  • Ataxia
  • Visual disturbances

Lithium may also cause:

  • Increased urination
  • Dry mouth
  • Difficulty concentrating
  • Tremors
21
Q

Schizophrenia

A
  • Chronic major psychosis that is characterized by delusions of thought, visual and/or auditory hallucinations
  • Thought to be associated with excess dopamine levels
22
Q

Treatment of Schizophrenia

A

-Drugs that block the transmission of signals in the dopaminergic system are used

23
Q

Drugs Used to Treat Schizophrenia and Psychoses

A
  • Neuroleptics

- Antipsychotics

24
Q

Neuroleptics

A

-Classified and “typical” or “atypical”

25
Q

Typical Neuroleptics

A
  • Have a strong affinity for dopamine receptors and produce more side effects
  • Classified as low, medium, and high potency
  • Low: chlorpromazine
  • Medium: fluphenazine
  • High: haloperidol
26
Q

Classes of Typical Neuroleptics

A
  • Phenothiazines
  • Butyrophenones
  • Thioxanthines
27
Q

Typical Neuroleptics ADR’s

A
  • Sedation and confusion
  • Weight gain/increased appetite
  • Blurred vision
  • Postural hypotension
  • Hepatotoxicity
  • Bone marrow suppression
  • Photosensitivity
28
Q

Atypical Neuroleptics

A
  • Have a weaker affinity for dopamine and produce fewer side effects
  • Clozapine and risperidone are prototypes
29
Q

Atypical Neuroleptics ADR’s

A
  • Sedation
  • Headache
  • Dizziness
  • Hypotension
  • Neutropenia
  • Nausea
  • Dry mouth
  • Sexual dysfunction
30
Q

Parkinson’s Disease

A
  • Progressive disorder of the nervous system involving degeneration of dopaminergic neurons
  • Symptoms associated with an imbalance of dopamine and acetylcholine
31
Q

Treatment of Parkinson’s Disease

A
  • Administering drugs that are synthesized to dopamine
  • Promote the release of existing stores of dopamine
  • Directly stimulate dopamine receptors
  • Inhibit degradation of dopamine in the terminal neuron
  • Anticholinergics to decrease acetylcholine
32
Q

Alzheimer’s Disease

A
  • A Neurodegenerative disease that causes memory loss and behavioral changes
  • Plaques and tangles develop in the brain which interfere with the transmission of signals between neurons
33
Q

Drug Treatment for Alzheimer’s Disease

A
  • Increase ACh levels at the synapse

- Block glutamate activity at the NMDA receptor

34
Q

Acetylcholinesterase Inhibitors

A
  • Acetylcholinesterase is an enzyme that causes the breakdown of ACh
  • AChE inhibitors increase the levels of ACh
35
Q

N-Methyl-D-Aspartate Receptor Inhibitors

A

-memantine blocks the actions of glutamate at the NMDA receptor sites

36
Q

Alzheimer’s Drugs ADR’s

A
  • Abdominal cramping
  • Dizziness
  • Diarrhea
  • Nausea
  • Sedation, tremors, hypotension
  • Increased urination
  • MI, erectile dysfunction, and suicide ideation (memantine)