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Collège Royal Psychiatrie > Cytochromes > Flashcards

Cytochromes Flashcards

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1
Q

Fluvoxamine et CYP

A

Substrat 1A2

Fort inhibiteur 1A2 et 2C19
Moyen inhibiteur 2D6, 3A4 et 2C9

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2
Q

Sertraline et CYP

A

Substrat 3A4, 2D6 et 2C19

Moyen inhibiteur 2D6

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3
Q

Fluoxétine et CYP

A

Substrat 2D6

Fort inhibiteur 2D6
Inhibiteur 2C19
Norfluoxétine (métabolite actif de la fluoxétine) : moyen inhibiteur 3A4

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4
Q

Citalopram et CYP

A

Substrat 2C19

Inhibiteur 2D6

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5
Q

Escitalopram et CYP

A

Substrat 2C19

Inhibiteur 2D6

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6
Q

Paroxétine et CYP

A

Substrat 2D6

Fort inhibiteur 2D6
Faible inhibiteur 2C9 et 2C19 (augmente la concentration de warfarine)

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7
Q

Venlafaxine et CYP

A

Substrat 3A4 et 2D6 (=>desvenlafaxine)

Légère inhibition 2D6

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8
Q

Mirtazapine et CYP

A

Substrat 2D6 et 1A2

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9
Q

Bupropion et CYP

A

Substrat 2B6 (et non 2D6)

Inhibiteur 2D6

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10
Q

Duloxétine et CYP

A

Substrat 2D6 et 1A2

Faible inhibiteur 2D6

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11
Q

Rispéridone et CYP

A

Substrat 2D6 (en palipéridone) et 1A2

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12
Q

Aripiprazole et CYP

A

Substrat 3A4 et 2D6

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13
Q

Clozapine et CYP

A

Substrat 3A4 et 1A2

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14
Q

Quétiapine et CYP

A

Substrat 3A4

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15
Q

Ziprasidone et CYP

A

Substrat 3A4

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16
Q

Halopéridol et CYP

A

Substrat 2D6 et 1A2

Inhibiteur 2D6

17
Q

Moclobémide et CYP

A

Substrat 2C19

Inhibiteur 2D6

18
Q

Inhibiteurs universels CYP

A

Acide valproïque
Cimétidine

19
Q

Inhibiteurs du 3A4 (non psychotropes)

A

Macrolides sauf azithromycine : clarithromycine et érythromycine
Antifongiques : kétoconazole, itraconazole, fluconazole
Oméprazole
Inhibiteurs de la protéase
Vérapamil
Diltiazem
Jus de pamplemousse
Amiodarone
Cyclosporine

20
Q

Inhibiteurs du 2D6 (non psychotropes)

A

Célécoxib
Cimétidine
Méthadone
Quinidine
Ranitidine
Terbinafine
Amiodarone
Ritonavir

21
Q

Inhibiteurs du 1A2 (non psychotropes)

A

Amiodarone
Cimétidine
Ciprofloxacine
Quinolones

22
Q

Inhibiteurs du 2C19

A

Anti-acides : cimétidine, lansoprazole, oméprazole
Kétoconazole

Oxcarbazépine
Topiramate

23
Q

Inhibiteurs du 2C9

A

Amiodarone
Fluconazole
Sulfaméthoxazole
Isoniazide

24
Q

Contraceptifs oraux sont substrats de…

A

3A4

25
Q

Corticostéroïdes sont substrats de…

A

3A4

26
Q

Carbamazépine et CYP

A

Substrat 3A4

Inducteur universel : 3A4, 2D6 et 2C19

27
Q

Sildenafil substrat de…

A

3A4

28
Q

Bêta-bloqueurs substrats de…

A

2D6

29
Q

Warfarine substrat de…

A

1A2 et 2C19 (R-warfarine)
2C9 (S-warfarine)

30
Q

Acétaminophène substrat de…

A

1A2

31
Q

Topiramate et CYP

A

Substrat 2C19

Inhibiteur 2C19

32
Q

Phénytoïne et CYP

A

Substrat 2C9

Inducteur 3A4 et 2D6

33
Q

Millepertuis et CYP

A

Induction 3A4

34
Q

Rifampin et CYP

A

Inducteur universel (3A4, 2D6, 1A2, 2C19 et 2C9)

35
Q

Efavirenz et CYP

A

Inducteur 3A4

36
Q

Clomipramine et CYP

A

Substrat 1A2 et 2C19

Collège Royal Psychiatrie (69 decks)

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