Viruses/Fungi 7 Flashcards
How many fungi can cause human infection?
over 200 species
fungi are most problematic in these pts
immunocompromised
systemic antifungal agents are used for
tx of deep (invasive) infections
- Candida
- Cryptococcus
IV systemic antifungal agent
Amphotericin B (Amphocin, Fungizone)
These are better tolerated, but may not be as effective as amphotericin B
Fluconazole (Diflucan)
Diflucan administration
IV or oral
side effects of amphotericin B
- HA
- joint and muscle pain
- fever
- weakness
- GI upset
side effects of Diflucan
- hepatotoxic
- severe skin rxns (S-J syndrome)
- HA
- GI upset
When would a local antifungal be chosen?
when antifungals are too toxic to be administered systemically
Lamisil used for these
- tinea pedis
- tinea cruris
- ringworm
-azole antifungals used for
Candida infections (skin/membranes)
local antifungal agents: side effects
- mild
- usually local
Malaria historically treated with this since the 17th century
quinine
Malaria now treated withy derivatives of this
chloroquine
adverse effects of antiprotozoal drugs
- vary
- GI
- HA
most common protozoan infectious agent
Toxoplasma gondii
Toxoplasma gondii found here
- many animals and birds
- reproduces in cats
- found in cat feces
toxoplasmosis
- flu-like symptoms
- parasites are walled off in cysts in the affected organs
What is a helminth?
parasitic worm
Examples of helminths
- tapeworms
- roundworms
- flukes
helminth route of infection
- ingestion of eggs in contaminated food and water
- eggs hatch
- adult worm lodge in tissue
- steal nutrients from host
Which drugs are used for helminthes?
-azoles
