Viruses/Fungi 7

Question 1

How many fungi can cause human infection?

Answer 1

over 200 species

Question 2

fungi are most problematic in these pts

Answer 2

immunocompromised

Question 3

systemic antifungal agents are used for

Answer 3

tx of deep (invasive) infections

• Candida
• Cryptococcus

Question 4

IV systemic antifungal agent

Answer 4

Amphotericin B (Amphocin, Fungizone)

Question 5

These are better tolerated, but may not be as effective as amphotericin B

Answer 5

Fluconazole (Diflucan)

Question 6

Diflucan administration

Answer 6

IV or oral

Question 7

side effects of amphotericin B

Answer 7

• HA
• joint and muscle pain
• fever
• weakness
• GI upset

Question 8

side effects of Diflucan

Answer 8

• hepatotoxic
• severe skin rxns (S-J syndrome)
• HA
• GI upset

Question 9

When would a local antifungal be chosen?

Answer 9

when antifungals are too toxic to be administered systemically

Question 10

Lamisil used for these

Answer 10

• tinea pedis
• tinea cruris
• ringworm

Question 11

-azole antifungals used for

Answer 11

Candida infections (skin/membranes)

Question 12

local antifungal agents: side effects

Answer 12

• mild

- usually local

Question 13

Malaria historically treated with this since the 17th century

Answer 13

quinine

Question 14

Malaria now treated withy derivatives of this

Answer 14

chloroquine

Question 15

adverse effects of antiprotozoal drugs

Answer 15

• vary
• GI
• HA

Question 16

most common protozoan infectious agent

Answer 16

Toxoplasma gondii

Question 17

Toxoplasma gondii found here

Answer 17

• many animals and birds
• reproduces in cats
• found in cat feces

Question 18

toxoplasmosis

Answer 18

• flu-like symptoms

- parasites are walled off in cysts in the affected organs

Question 19

What is a helminth?

Answer 19

parasitic worm

Question 20

Examples of helminths

Answer 20

• tapeworms
• roundworms
• flukes

Question 21

helminth route of infection

Answer 21

• ingestion of eggs in contaminated food and water
• eggs hatch
• adult worm lodge in tissue
• steal nutrients from host

Question 22

Which drugs are used for helminthes?

Answer 22

-azoles