Ciccone Doc 3 Flashcards
Drug types that inhibit bacterial protein synthesis
- Erythromycin
- Tetracycline
- Chloromycetin
- Clindamycin
- Ketek
Specificity of drugs that inhibit protein synthesis
very broad spectrum
- affects gram +/-
- no specificity
Why are drugs that inhibit bacterial protein synthesis not used with children?
- nephrotoxicity
- ototoxicity
Erythromycin useful in
airway infections
When a pt is on erythromycin, need to monitor
liver function
Erythromycin hits these types of bacteria
Gram +/-
Overall effects tetracycline may have
- anti-inflammatory
- neuroprotective
- immunomodulation
Tetracyclines are being investigated for use in
- Parkinson’s
- cancer
- dermatological condition (rosacea)
- CVD
With tetracycline, you should look out for
- photosensitivity
- interference with osteoblast/clasts in bone remodeling (useful in adults)
Tetracycline causes permanent discoloration of:
- teeth (kids)
- bone
- skin
When is chloromycetin used?
reserved for non-responsive infections
What may chloromycetin lead to?
aplastic anemia
This drug predisposes a pt to getting C-diff
Clindamycin
black box warning for it!
What type of drug is Ketek?
ketolide antibacterials (new class of drugs)
Ketek is a derivative of
Erythromycin
