9.21 Injury, Inflammation, Healing 6 Flashcards
What is the general term for WBCs?
leukocytes
What is the pneumonic for the types of leukocytes?
Never Let Monkeys Eat Bananas
What does Never Let Monkeys Eat Bananas stand for?
types of leukocytes
- Neutrophils
- Lymphocytes
- Monocytes
- Eosinophils
- Basophils
What are neutrophils?
the predominant phagocytes in the early inflammatory process
When do neutrophils arrive on the scene?
6-12 hours after initial injury
first on the job
neutrophils and cell division/lifespan
- incapable of cell division
- short lived
What happens to neutrophils when they die?
- become part of exudate/pus
- removed from body
What are the primary roles of neutrophils?
- remove debris and dead cells from sterile lesions
- phagocytosis of bacteria in nonsterile lesions
What do lymphocytes mature into?
- T cells
- B cells
- plasma cells
Lymphocytes are important in _____
immunity
Concentrations of lymphocytes
Won’t see in large concentrations unless there’s something like leukemia going on
Which are the largest of the normal blood cells?
monocytes
Monocytes are produced here
bone marrow
After entry into the _______, monocytes enter _______ to develop into ________
- inflammatory site
- circulation
- macrophages
Monocytes replace _______ 24 hours after injury
neutrophils
Monocytes are useful for this
long term defense
Monocytes are seen in higher proportions in ___________
chronic inflammation
Body’s primary defense against parasites
eosinophils
How do eosinophils act?
- mildly phagocytic
- help regulate vascular mediators released by mast cels
- helps to limit inflammation
What are basophils?
- mobile mast cells
- release similar inflammatory agent to eosinophils (?)
Characteristics of chronic inflammation
- dense infiltration of lymphocytes and macrophages
- granuloma formation
- epithelioid cell formation
- giant cell formation
Components of the inflammatory rxn
- vascular alterations
- leukocyte accumulations
- chemical mediation of inflammation
- phagocytosis
