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8501 Clin Med > MS 5 > Flashcards

MS 5 Flashcards

1
Q

Medications for MS do this:

A
  • modify disease course
  • treat attacks
  • manage symptoms
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2
Q

How many disease-modifying agents approved by the FDA?

A

14

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3
Q

Types of disease-modifying agents that can be used to treat MS

A
  • self-injectables
  • oral
  • IV
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4
Q

How many self-injectables are available to treat MS?

A

8

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5
Q

How many oral drugs are available to treat MS?

A

3

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6
Q

How many IV drugs are available to treat MS?

A

3

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7
Q

Drug type: Natalizumab (Tysabri)

A

IV

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8
Q

Drug type: Teriflunomide (Aubagio)

A

Oral

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9
Q

Drug type: Fingolimod (Gilenya)

A

Oral

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10
Q

Drug type: Interferon beta 1-a (Avonex and Rebif)

A

Self-injectable

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11
Q

Drug type: Interferon beta 1-b (Betaseron and Extavia)

A

Self-injectable

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12
Q

Drug type: Daclizumab (Zinbryta)

A

Self-injectable

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13
Q

Drug type: Dimethyl fumarate (Tecfidera)

A

Oral

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14
Q

Drug type: Mitoxantrone (Novantrone)

A

IV

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15
Q

Drug type: Glatiramer acetate (Copaxone and Glatopa)

A

Self-injectable

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16
Q

Drug type: Peginterferon beta 1-a (Plegridy)

A

Self-injectable

17
Q

Drug type: Alemtuzumab (Lemtrada)

A

IV

18
Q

Why is early tx so early with MS?

A

Neuroinflammation and neurodegeneration occur early in the disease course

19
Q

Individuals with first clinical event with MRI findings consistent with MS have:

A

high probability of further disease activity

20
Q

Significance of early disease activity

A

Likely impacts long-term disability

21
Q

What types of cognitive/emotional changes occur early on in MS?

A
  • cognitive changes
  • depression
  • fatigue
22
Q

Impact of tx following first clinical event

A
  • Delay conversion to definite MS

- Reduce brain atrophy and disability worsening

23
Q

Why does tx need to be ongoing for MS?

A
  • once tx is initiated, it needs to be ongoing for benefits to continue
  • cessation negatively impacts outcomes
  • relapse rates can return to baseline if tx is interrupted
24
Q

What happens to FSS and EDSS scores if tx is stopped and relapse rates return to baseline?

A

both increase

25
Q

rationale for access to full range of tx options: use of interferon beta and natalizumab

A
  • frequently associated with development of neutralizing antibodies
  • reduces clinical efficacy
26
Q

rationale for access to full range of tx options: contraindications, nonresponders

A

need access to options

27
Q

rationale for access to full range of tx options: severity of disease

A
  • varies at onset

- some experience early aggressive disease

28
Q

rationale for access to full range of tx options: African Americans

A

Some have more active disease

29
Q

rationale for access to full range of tx options: adherence

A

Some people don’t adhere to tx regimen and need access to options

8501 Clin Med (102 decks)

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