Study Guide 7

Question 1

Protein implicated in PD

Answer 1

N/A

Question 2

Region of the brain most affected in PD

Answer 2

BG in cerebrum and midbrain

Question 3

Which cell types are targeted first in PD?

Answer 3

Dopaminergic

Question 4

Structural changes in brain with PD

Answer 4

None, minus cell death in BG

Question 5

Cell death in the BG with PD - specific areas affected

Answer 5

• substantia nigra compacta

- PPN

Question 6

Levodopa side effects

Answer 6

• N/V
• arrhythmias
• OH
• dyskinesia
• behavioral changes

Question 7

What is it called when PD medication wears off before the next dose?

Answer 7

End of dose akinesia

Question 8

What helps with end of dose akinesia?

Answer 8

Twice a day scheduling

Question 9

What is the phenomenon with PD where meds fluctuate in effectiveness and you get freezing?

Answer 9

On/off phenomenon

Question 10

What can be done to combat loss of effectiveness of PD drugs?

Answer 10

Take a drug holiday

Question 11

Proteins implicated in AD

Answer 11

• amyloid plaques (accumulate extracellularly)

- tau (accumulate intracellularly)

Question 12

Area of the brain targeted first in AD

Answer 12

Hippocampus

Question 13

What results from AD targeting the hippocampus first? (S/s)

Answer 13

• memory loss
• cognition loss
• executive function loss

Question 14

What neuronal cell types are targeted first with AD?

Answer 14

Cholinergic

Question 15

What structural changes occur in the brain with AD?

Answer 15

Widespread inflammation and death of cholinergic cells in the limbic system

Question 16

Medication to treat AD inhibit this

Answer 16

ACH breakdown

Question 17

General categories of treatment for AD

Answer 17

• behavioral management
• medication
• hormone replacement
• ginkgo biloba

Question 18

Caution with ginkgo

Answer 18

Use cautiously in pts at risk for bleeding or on blood thinners

Question 19

Pick’s dz is a type of

Answer 19

Frontotemporal dementia

Question 20

Potential cause of Pick’s dz

Answer 20

Misfolded proteins (ubiquitin system)

Question 21

What structural changes can occur in the brain with frontotemporal dementia?

Answer 21

Accumulation of misfolded proteins

Question 22

What areas of the brain are targeted first with Lewy body dementia?

Answer 22

• BG

- brainstem

Question 23

Which neuronal cell types are targeted first with Lewy body dementia?

Answer 23

Dopaminergic

Question 24

What structural changes can occur in the brain with Lewy body dementia?

Answer 24

Marked inflammation and neuronal death in the BG and brainstem

Question 25

General tx for Lewy body dementia

Answer 25

None discussed in class

Question 26

Protein implicated with CTE

Answer 26

Tau