9.29 Immunity 5

Question 1

How is the immune response modulated?

Answer 1

• immune suppression

- immunostimulants

Question 2

Why would immune suppression be used?

Answer 2

• prevent rejection of transplanted organs/tissues

- limit immune-mediated damage to the body’s tissues (suppress autoimmune response)

Question 3

Immunostimulants are beneficial for

Answer 3

• compromised immune function

- chronic infections

Question 4

Complex: may result in resemblance of autoimmune disease

Answer 4

immunostimulants

Question 5

Which are used more commonly? Immunosuppressants or immunostimulants?

Answer 5

immunosuppressants

Question 6

Antibodies, Azathioprine, Cyclosporine, Glucocorticoids, Methotrexate, and Prograv (tacrolymus) are all:

Answer 6

immunosuppressants

Question 7

Antibodies are used in:

Answer 7

• prevention of bone marrow transplant rejection

- hemolytic disorders

Question 8

Azathioprine is used for:

Answer 8

• prevention of transplant rejection
• RA
• IBS
• MG
• lupus

Question 9

Cyclosporine is used for:

Answer 9

• prevention of transplant rejection
• RA
• psoriasis

Question 10

Glucocorticoids are used for:

Answer 10

• transplant rejection
• MS
• RA
• hemolytic disorders

Question 11

Methotrexate is used for:

Answer 11

• RA

- psoriasis

Question 12

Prograv (tacrolymus) is used a lot with this

Answer 12

liver transplants for rejection

Question 13

These are the big intense anti-inflammatory agents that cause big immune suppression

Answer 13

glucocorticoids

Question 14

What is leukopenia?

Answer 14

leukocyte formation is suppressed

Question 15

General adverse effects of immunosuppressants?

Answer 15

• leukopenia
• GI distress
• organ toxicities (nephrotoxicity)
• increased infections

Question 16

What are adverse effects of glucocorticoids (immunosuppressants)

Answer 16

• breakdown of collagenous tissue
• growth retardation in children
• etc.

Question 17

What are the immunostimulants?

Answer 17

• Bacille Calmette-Guerin

- Immune Globulin

Question 18

What is Bacille Calmette-Guerin?

Answer 18

• active bacterial strain used as a vaccine against TB

- administered locally in the bladder for the tx of bladder cancer

Question 19

Most common use for Bacille Calmette-Guerin

Answer 19

bladder cancer

Question 20

adverse rxns for Bacille Calmette-Guerin?

Answer 20

• irritation at injection site
• skin irritation
• infection

Question 21

How is immune globulin prepared?

Answer 21

by extracting immunoglobulins from donated human blood

Question 22

Immune Globulin is primarily

Answer 22

IgG

Question 23

How is Immune Globulin administered and what is its primary function?

Answer 23

• via IV

- immunodeficiency syndromes, Guillain-Barré, relapsing remitting MS

Question 24

adverse rxns for Immune Globulin

Answer 24

• joint and muscle pain
• HA
• malaise
• Gi disturbance

Question 25

Clients with autoimmune disorders taking immunosuppressants will likely be (better/worse) able to participate in PT?

Answer 25

better able to participate

Question 26

What is critically important with an immunosuppressed pt and PT?

Answer 26

• make sure tx space is clean

- avoid introducing pathogens