9.19 Injury, Inflammation, Healing 3

Question 1

goal of tissue healing

Answer 1

restore function if possible

Question 2

What is necessary for tissue return to function?

Answer 2

regeneration

Question 3

tissue regeneration

Answer 3

• not possible in all tissue (neuron, cardiac muscle)

- new research is promising

Question 4

repair of connective tissue

Answer 4

• scarring

- muscle fibrosis

Question 5

repair: maintains integrity of the tissue but does NOT

Answer 5

function as original cells and tissues

Question 6

components that help with the repair process

Answer 6

• fibronectin
• proteoglycan and elastin
• collagen

Question 7

fibronectin

Answer 7

• tensile strength

- glue

Question 8

proteoglycans and elastin

Answer 8

fibroblast proliferation

Question 9

collagen

Answer 9

• fibrous protein

- structural support and tensile strength of tissue

Question 10

What is the most important protein that provides structural support?

Answer 10

collagen

Question 11

Factors that affect healing?

Answer 11

• growth factors
• vascular supply
• age, tissue health, disease, psychological status, alcohol, smoking, nutrition, tissue type, meds, etc.

Question 12

What are the phases of healing?

Answer 12

1. hemostasis and degeneration phase
2. inflammation phase
3. proliferation and migration phase
4. remodeling and maturation phase

Question 13

hemostasis and degeneration phase

Answer 13

• initiation phase

- stops bleeding

Question 14

inflammation phase

Answer 14

prepares for healing

Question 15

proliferation and migration phase

Answer 15

rebuilds and strengthens damaged tissue

Question 16

remodeling and maturation phase

Answer 16

modifies tissue to mature form

Question 17

How is bleeding stopped in the hemostasis and degeneration phase?

Answer 17

• immediately

- coagulation cascade

Question 18

Coagulation cascade involves

Answer 18

• platelets
• growth factors
• proliferation and migration of epithelial cells
• fibroblasts
• vascular endothelial cells

Question 19

What happens during degeneration?

Answer 19

• hematoma formed
• necrosis of dead cells
• inflammatory response of fluid, neutrophils, and macrophages begins

Question 20

degeneration: tissue healing begins within

Answer 20

24 hours

Question 21

degeneration: fibroblast migration

Answer 21

fibroblasts migrate from margins of viable tissue to the defect area

Question 22

Proteins secreted during degeneration phase

Answer 22

• fibronectin
• proteoglycans
• elastin
• collagen

Question 23

What happens between degeneration and inflammation?

Answer 23

proliferation and migration of epidermal cells