Screening 5 Flashcards

1
Q

Leukocyte disorders are recognized as the body’s reaction to

A
  • disease

- foreign invaders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two leukocyte disorders we discussed?

A
  • leukocytosis

- leukopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

leukocytosis =

A

increased neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

leukopenia =

A

too few leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Too few leukocytes (leukopenia) is related to

A
  • bone marrow failure

- never a beneficial condition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

s/s of leukocytosis

A
  • fever
  • sx of localized or systemic infection
  • inflammation
  • tissue trauma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

s/s of leukopenia

A
  • sore throat
  • cough
  • high fever/chills
  • ulcerations
  • persistent infections
  • frequent/painful urination
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When is leukopenia commonly seen?

A
  • following chemotherapy

- consider nadir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the nadir?

A

WBC count is at lowest level as a result of cancer tx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Important considerations for a pt at a nadir

A

If we know they will reach the nadir, must remember that they are more susceptible to infections during this time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Leukopenia: When does the nadir generally occur after cancer tx?

A

Usually between 7-14 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the platelet disorders we discussed?

A
  • thrombocytosis

- thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Thrombocytosis is an increase in

A

platelet count

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Why/when does thrombocytosis usually occur?

A

usually compensatory and temporary after surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What factors can influence platelet count?

A
  • diet
  • exercise
  • liver disease
  • radiation
  • chemotherapy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are two nutritional factors that influence platelet count?

A
  • lecithin

- vitamin K

17
Q

Lecithin (prevents/promotes) coagulation

A

prevents

18
Q

Vitamin K (prevents/promotes) coagulation

A

promotes

19
Q

How does exercise impact coagulation?

A

helps destroy clots

20
Q

clinical s/s of thrombocytosis

A
  • easy bruising
  • splenomegaly
  • thrombosis
21
Q

Why does splenomegaly occur with thrombocytosis?

A

It becomes enlarged because it has to work much harder

22
Q

What is thrombocytopenia?

A

decreased platelet count

23
Q

What can thrombocytopenia result from?

A

decreased or defective platelet production

24
Q

What causes thrombocytopenia?

A
  • bone marrow failure
  • leukemia
  • medications
25
Q

Which medications can cause thrombocytopenia?

A
  • NSAIDs
  • methotrexate
  • gold
  • coumadin
26
Q

clinical s/s of thrombocytopenia

A
  • bleeding after minor trauma
  • spontaneous bleeding
  • gingival bleeding
27
Q

Where might you see idiopathic thrombocytopenia?

A

children

28
Q

PT must be on alert for obvious sx of thrombocytopenia: Why?

A
  • exercise that involves straining could precipitate a hemorrhage
  • esp. of eyes or brain
29
Q

undiagnosed clients with sx of thrombocytopenia

A

need immediate physician referral

30
Q

Why is COX so important for platelets?

A

COX is an enzyme needed for thromboxane A2

»»» platelet aggregation and arterial smooth muscle constrictor «««

31
Q

These two drugs activate platelet COX

A
  • Aspirin (ASA)

- NSAIDs

32
Q

A single dose of this can suppress normal platelet aggregation for 48 hours up to a week

A

ASA

33
Q

Why is ASA problematic for platelet aggregation?

A
  • irreversibly inhibits COX

- platelets are inactivated for the rest of their lifespan

34
Q

How long do platelets live?

A

about 8 days

34
Q

NSAIDs effects on COX are ________

A

reversible

36
Q

Effects of NSAIDs on platelets

A

milder than ASA

  • bruising
  • skin bleeding
37
Q

platelets and NSAIDs: pre-op implications

A

safest to d/c NSAIDs preop, even though effects are milder