9.7 Pharmacology 5 Flashcards
bioavailability
extent to which drug reaches systemic circulation
What does bioavailability depend on?
- route of administration
- drug’s ability to cross membrane barriers
drug movement
- passive diffusion
- active transport
- facilitated diffusion
- endocytosis
Why does ionization state affect absorption?
pH of digestive system interacts with the drug
- excretion
- how quickly and easily it is to get rid of the drug
clearance rate
volume of distribution
people who weight more require larger amts of the medicine for it to work
factors affecting distribution of drugs in the body
- tissue permeability
- blood flow
- binding to plasma proteins
- binding to subcellular components
- volume of distribution
major tissue permeability concern
blood brain barrier
blood flow and distribution of drugs in the body
- drugs have higher access to well-perfused areas
- why foot wounds don’t heal unless peripheral blood flow is adequate
Which drugs can reach a target to create a pharmacologic effect?
only unbound or “free” drugs
bound drugs
- drug remains bound to a protein and is sequestered in the vascular system
- doesn’t produce a therapeutic response
binding to subcellular components
- drug is “trapped” by organelles within a cell
- can’t be distributed to other target areas
example of subcellular binding
certain antidepressants and antipsychotics with relatively high pH are attracted to the acidic lysosome
volume of distribution: important considerations
- may be possible to increase dosage to achieve therapeutic effect
- only if TI permits
What tissues might drugs be stored in that could have adverse effects?
- adipose tissue
- bone
- muscle
- organs
