Ciccone Doc for Pharm Flashcards
selective toxicity
- kills or attenuates pathogen growth
- no excessive damage to host
Bacteria are structurally capable of independent life, but need this
nourishing host
Broad spectrum antibacterial agents
- kill everything
- no specificity
What does the lack of specificity of broad spectrum antibacterial agents lead to?
- less effective later on
- some bacteria will already have a tolerance built up
bactericidal
- is bacteriostatic
- limits growth and proliferation
Why is it common to see N/V with antibiotics?
they’re cleaning out intestinal flora
When can drug resistance occur? What does this mean?
- can occur with overprescription of antibiotics
- must be mindful of prescribing so that it won’t have such a huge impact
Basic mechanisms of action: Where do antibacterial agents differ?
location at which they impact the bacteria
Where might antibacterial agents act?
- cell membrane synthesis
- cell wall synthesis
- inhibit protein synthesis
- inhibit DNA/RNA synthesis
What are the drugs that act on cell membrane synthesis?
- Penicillins
- Cephalosporins
- Carbapenems
What are the drugs that act on cell wall synthesis?
- Topical (i.e. bacitracin)
- Vancomycin
What are the drugs that act on protein synthesis?
- Erythromycin
- Tetracycline
- Chloromycetin
- Clindamycin
- Ketek
What are the drugs that act on DNA/RNA synthesis?
- Fluoroquinolones
- Sulfanomides
