Immunodeficiency 1 Flashcards
Immunodeficiency occurs as a result of:
result of either a primary or secondary disorder
A primary immunodeficiency disorder occurs from a defect involving:
- T cells
- B cells
- lymphoid tissues
A secondary immunodeficiency disorder occurs because of:
Underlying factor or disease that suppresses or blocks the immune response
Iatrogenic immunodeficiency is induced by one of these:
- immunosuppressive drugs
- radiation therapy
- splenectomy
What are immunosuppressive drugs that can cause iatrogenic immunodeficiency?
- cytotoxic drugs
- corticosteroids
- cyclosporine
- anti-lymphocyte serum
How much of the immune tissue lies in the gut?
2/3
Major central organs of the immune system
- thymus gland
- bone marrow
Major peripheral organs of the immune system
- tonsils
- lymph nodes
- spleen
- interstitial lymphoid tissue
What is a major site of interstitial lymphoid tissue?
Peyers patches
What are the effects of radiation therapy on the immune system?
- cytotoxic to lymphocytes
- profound lymphopenia
What is total nodal irradiation?
radiation of all major lymph node areas
What is total nodal irradiation used for?
Hodgkins lymphoma
What is Hodgkins lymphoma?
cancer of the lymphatic system
Total nodal irradiation has been investigated for use in these:
- severe RA
- lupus nephritis
- kidney transplant rejection
What are the consequences of immunodeficiency?
- increased risk of developing infection
- Normal mechanical defense mechanisms are affected (respiratory, GI, etc.)
