MS 2 Flashcards
A primary demyelinating disorder includes direct damage by:
inflammatory cells
A primary demyelinating disorder includes indirect damage by:
extracellular environment
With a primary demyelinating disorder, neurons become more susceptible to
apoptosis
Nerve recovery following myelin damage
after damage, nerve conduction properties can recover
Why are nerves able to recover following myelin damage?
redistribution of Na channels
MS is primarily a ______ inflammatory disorder
T cell mediated
It is hypothesized that preexisting autoreactive T cells are activated by:
- foreign microbes
- self-proteins
- microbial superantigens
What is overproduced with MS? (inflammatory)
cytokines
In MS, an excessive amount of _____ is released by lymphocytes and macrophages
glutamate
What is a plaque? Where are they formed?
focal abnormalities that spread through cerebral hemispheres
Main areas of plaque occurrence
- surrounding ventricles
- optic nerves
- brainstem
Acute lesions
- pink
- faint borders
Chronic lesions
- gray
- firm
- sharp edges
What are the main pathologic conditions of MS?
- inflammation
- demyelination
- axon loss
What is long term disability primarily caused by with MS?
- irreversible axon loss
- cell death
