Pharm 5 Flashcards

1
Q

What are the classes of sedative-hypnotic drugs?

A
  • benzodiazepines
  • non-benzodiazepines (barbiturates)
  • non-benzodiazepines (sedative hypnotics)
  • other nonbenzodiazepines
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2
Q

Sedative hypnotic drugs:

Benzodiazepines

A
  • Halcion

- Restoril

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3
Q

Sedative hypnotic drugs:

Non-benzodiazepines (barbiturates)

A
  • Luminal/phenobarbital
  • Nembutal/pentobarbital
  • Seconal/secobarbital
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4
Q

Sedative hypnotic drugs:

Non-benzodiazepines sedative hypnotics

A
  • Ambien
  • Sonata
  • Lunesta
  • Rozerem
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5
Q

Sedative hypnotic drugs:

Other non-benzodiazepines

A

Tylenol
Advil PM
Benadryl
Nyquil

Etc.

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6
Q

Anti-anxiety drugs: classes

A
  • benzodiazepines

- antidepressants

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7
Q

Anti-anxiety drugs:

Benzodiazepines

A
  • Valium
  • Xanax
  • Ativan
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8
Q

Anti-anxiety drugs:

Antidepressants

A
  • Cymbalta
  • Lexapro
  • Paxil
  • Zoloft
  • Effexor
  • XR
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9
Q

Which drug classes are used as anti-seizure drugs?

A
  • Barbiturates
  • Benzodiazepines
  • Hydantoins
  • Iminostilbenes
  • Succinimides
  • Valproates
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10
Q

Which benzodiazepines are helpful for acute status epilepticus (not long term)?

A
  • Valium

- Ativan

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11
Q

Anti-seizure drugs:

Hydantoins - off-label use

A

Neuropathic pain

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12
Q

Anti-seizure drugs:

Hydantoins - adverse effects

A
  • cerebellar signs

- gingival hyperplasia

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13
Q

Anti-seizure drugs: How do iminostilbenes work?

A

By slowing recovery of Na+ channels from firing too rapidly

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14
Q

Anti-seizure drugs:

Iminostilbenes - adverse effects

A

issues with salt imbalances

  • water retention
  • antidiuretic hormone release
  • cardiac arrhythmias
  • CHF
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15
Q

Anti-seizure drugs: example of a succinimide drug

A

Zarontin

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16
Q

In addition to seizures, valproate are also used to treat

A

BP

17
Q

This drug class is used to treat absence seizures

A

Succinimides (Zarontin)

18
Q

What are 2nd generation anti-seizure drugs?

A

Used as an add-on to first gen drugs (“specialty drugs”)

19
Q

Which are the two second generation anti-seizure drugs?

A
  • gabapentin

- lyrica

20
Q

Adverse effects of gabapentin (and other anti-anxiety drugs)

A
  • sedation
  • fatigue
  • dizziness
  • ataxia
21
Q

Adverse effects of lyrica

A
  • dizziness
  • drowsiness
  • peripheral edema
22
Q

How does Lyrica cause peripheral edema?

A

Inhibition of Ca2+ channels

23
Q

What is the 2nd gen anti-seizure drug, Lyrica, used for?

A

Chronic pain

  • fibromyalgia
  • diabetic peripheral neuropathy
  • post-herpetic neuralgia