9.7 Pharmacology 3

Question 1

dose-response curve

Answer 1

dosage range over which the drug is effective, including peak response

Question 2

threshold dose

Answer 2

beginning of therapeutic response

Question 3

ceiling effect

Answer 3

no further increase in response

Question 4

What does the dose-response give indication of?

Answer 4

binding to cellular receptors

Question 5

potency

Answer 5

dose that produces a given response in a specific amplitude

Question 6

Drug A may have an effect at 10 mg, Drug B may require 80 mg to achieve same effect.

Which is more potent?

Answer 6

Drug A

less needed to provide the same response

Question 7

Potency does NOT predict

Answer 7

therapeutic effect

Question 8

quantal dose-response curve

Answer 8

percentage of the population that exhibits a specific response as the dosage is increased

Question 9

grading of quantal dose-response curve

Answer 9

not graded

either present or absent in each member of the population

Question 10

dose at which 50% of the population responds to the drug in a specified manner

Answer 10

median effective dose (ED_50)

Question 11

dose at which 50% of the population exhibits an adverse effect

Answer 11

median toxic dose (TD_50)

Question 12

dose which causes death of 50% of the animal test population

Answer 12

median lethal dose (LD_50)

Question 13

What is a major indicator of drug safety?

Answer 13

therapeutic index

Question 14

Large TI indicates:

Answer 14

a much larger dose is needed to evoke a toxic effect than it does to cause a therapeutic effect

Question 15

TI =

Answer 15

TI = (TD_50)/(ED_50)

Question 16

TI does not take these effects into account

Answer 16

long term

Question 17

Tylenol has a TI of

Answer 17

27

*shows liver toxicity with prolonged use

Question 18

diazepam (valium) has a TI of

Answer 18

3

Question 19

Drugs with a (low/high) TI are riskier

Answer 19

low