Tranexamic Acid

Question 1

Tranexamic Acid (TXA) Trade Name

Answer 1

Lysteda, Cyclokapron

Question 2

TXA Classification

Answer 2

Antifibrinolytic, Hemostatic Agent

Question 3

TXA Onset

Answer 3

5-15 minutes

Question 4

TXA Duration

Answer 4

2-5 hours

Question 5

TXA Indications

Answer 5

Per Mr. Fortin
Blunt or penetrating trauma with significant hypotension.
Any arterial bleeding that requires a tourniquet.

Question 6

TXA Contraindications

Answer 6

Per Mr. Fortin
> 3 hours from initial injury
Isolated head injury
Known coagulation disorder (i.e. hemophilia)
Suspected stroke or STEMI

Question 7

TXA Side Effects/ Precautions

Answer 7

Per Mr. Fortin
Seizures, dizziness, headache, fatigue, abdominal pain, nausea vomiting, diarrhea, back pain, DVT, PE
Rapid administration can cause hypotension

Question 8

TXA Adult dose

Answer 8

Per Mr. Fortin
1g in 100ml NS over 10 mins (max 1g)

Question 9

TXA Pediatric dose

Answer 9

Per Mr. Fortin
20 mg/kg in 100 ml NS over 10 mins (max 1g)

Question 10

TXA Routes of administration

Answer 10

IV/IO

Question 11

TXA How supplied

Answer 11

Capital: 1g vials
Note: TXA not carried by Danbury and not listed in CT State Protocols

Question 12

TXA Mechanism of Action

Answer 12

Per Mr. Fortin:
Synthetic derivative of amino acid lysine which then blocks lysine binding sites on
plasminogen, which inhibits fibrinolysis (fibrin clot degradation by plasmin).