Olanzapine

Question 1

Olanzapine Trade Name

Answer 1

(Zyprexa)
(Not carried by Danbury)

Question 2

Olanzapine Classification

Answer 2

Medscape:
Antipsychotics, 2nd Generation; Antimanic Agents

Capital:
Antipsychotic

Question 3

Olanzapine Mechanism

Answer 3

Medscape:
May act through combination of dopamine and serotonin type 2 receptor site antagonism

Capital:
Inhibits synaptic uptake of serotonin and norepinephrine to produce antipsychotic and anticholinergic effects

Question 4

Olanzapine Onset of Action

Answer 4

Capital: Rapid

Question 5

Olanzapine Duration of Action

Answer 5

Capital: 2-4 hrs

Question 6

Olanzapine Indications

Answer 6

Capital:
Acute psychosis, Alzheimer’s disease

CT Protocols:
Extreme agitation/combativeness, Suspected excited delirium, Ineffective control of agitated patient after benzodiazepines

Question 7

Olanzapine Contraindications

Answer 7

Capital:
Hypersensitivity

Question 8

Olanzapine Side Effects/ Precautions/ Comments

Answer 8

Capital:
Muscle pain, Somnolence, Dizziness, Tremor, Tachycardia, Hypotension, Nausea, Dry mouth

Increased CNS depression when used in conjunction with other CNS depressants

Use with caution in patients with cardiovascular disease or in patients with a predisposition to hypotension

Question 9

Olanzapine Adult Dose

Answer 9

CT Protocols:
Restraints: In conjunction with benzodiazepine, olanzapine 5 – 10 mg IM

Capital:
5-10 mg IM

Question 10

Olanzapine Pediatric Dose

Answer 10

Capital:
Not recommended

Question 11

Olanzapine
Max Dose Adult (Pediatric)

Question 12

Olanzapine Routes of Administration

Answer 12

IM

Question 13

Olanzapine How Supplied

Answer 13

10 mg vials