Methylprednisolone Flashcards
Methylprednisolone Trade Name
(Solu-Medrol)
Methylprednisolone Classification
Medscape:
Corticosteroids; Anti-Inflammatory Agents
Capital:
Corticosteroid
Methylprednisolone Mechanism
Medscape:
Potent glucocorticoid with minimal to no mineralocorticoid activity
Modulates carbohydrate, protein, and lipid metabolism and maintenance of fluid and electrolyte homeostasis
Controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level
Capital:
Inhibits pro-inflammatory substances and synthesis of pro-inflammatory enzymes; potentiates smooth muscle relaxation caused by beta-adrenergic agonists
Methylprednisolone Onset of Action
Capital: 1-2 hour
Methylprednisolone Duration of Action
Capital: 8-24 hours
Methylprednisolone Indications
Capital:
Anaphylaxis, Bronchoconstriction
CT Protocols:
Steroid used in respiratory distress to reverse inflammatory and allergic reactions.
Methylprednisolone Contraindications
Capital:
Hypersensitivity
Methylprednisolone Side Effects/ Precautions/ Comments
Capital:
Headache, Vertigo, CHF, Hypertension, Fluid and salt retention, Nausea
May blunt effects of anti-hypoglycemic agents
Solu-Medrol preferred for reactive airway disease and anaphylaxis; Solu-Cortef preferred for adrenal insufficiency
Methylprednisolone Adult Dose
CT Protocols:
Adrenal Insufficiency
* 125 mg IV/IO/IM
Asthma/COPD/RAD
* 125 mg IV/IO
Methylprednisolone Pediatric Dose
PALS
2 mg/kg IV/IO/IM (max 60mg)
Maintenance 0.5 mg/kg IV/IO q 6hrs (Max 120 mg/d)
Methylprednisolone
Max Dose Adult (Pediatric)
125mg (60mg)
Methylprednisolone Routes of Administration
IM, IV/IO
Methylprednisolone How Supplied
125 mg powders with diluent provided for reconstitution
