Alteplase Flashcards
Alteplase Trade Name
(tPA, Activase)
(Not carried by Danbury)
(Not in CT Protocols)
Alteplase Classification
Medscape:
Thrombolytic
Capital:
Fibrinolytic
Alteplase Mechanism
Medscape:
Recombinant human tissue-type plasminogen activator (t-PA); produces local fibrinolysis. Promotes thrombolysis by converting plasminogen to plasmin; plasmin degrades fibrin and fibrinogen
Capital:
Binds to fibrin-bound plasminogen at the clot site to convert plasminogen to plasmin. Plasmin digests the fibrin strands of the clot.
Alteplase Onset of Action
Capital: Clot lysis within 60-90 minutes
Alteplase Duration of Action
Capital: Clot lysis within 60-90 minutes
Alteplase Indications
Capital:
Acute MI, Pulmonary embolism, Ischemic stroke
Alteplase Contraindications
Capital:
Active internal bleeding, Surgery within 2-3 weeks, Previous CVA, Prolonged CPR,
Brain or spinal surgery within 3 months, Brain cancer, Aneurysm, Recent significant trauma (especially head trauma), Uncontrolled hypertension (>185/110)
Alteplase Side Effects/ Precautions/ Comments
Capital:
Intracranial bleeding, Headache, Reperfusion dysrhythmias, Chest pain, GI bleeding,
Nausea/vomiting, Abdominal pain, Hypotension
Aspirin, heparin and other anticoagulants may increase risk of bleeding
Closely observe patient for signs of bleeding, Only administered via IV pump, Invasive procedures (IV starts, IM/SQ injections, etc.) should be avoided during administration
Alteplase Adult Dose
Capital:
0.9 mg/kg; first 10% administered over one minute;
remaining 90% administered over 60 minutes
Alteplase Pediatric Dose
Capital:
Not recommended
Alteplase
Max Dose Adult (Pediatric)
?
Alteplase Routes of Administration
IV/IO
Alteplase How Supplied
50 mg and 100 mg powders that require reconstitution to a concentration of 1 mg/ml.
