Phenylephrine Flashcards
Phenylephrine Trade Name
(Vazculep, Biorphen, Neo-Synephrine )
(Not carried by Danbury)
Phenylephrine Classification
Medscape: Alpha1 Agonists, Sympathomimetic
Phenylephrine Mechanism
Medscape:
Strong alpha effects resulting in increased peripheral vascular resistance and blood pressure; decreases cardiac output and renal perfusion
Capital:
Binds to Alpha 1 adrenergic receptors to increase peripheral vascular resistance through profound vasoconstriction
Phenylephrine Onset of Action
Capital: Immediate
Phenylephrine Duration of Action
Capital: 15-20 Mins
Phenylephrine Indications
Capital:
Non-hypovolemic shock, especially distributive shocks
CT Protocols:
Hypotension in the peri-intubation period when using rapid sequence intubation
Phenylephrine Contraindications
Capital:
Hypovolemia, Tachydysrhythmia
CT Protocols:
Hypersensitiviy, Ventricular tachycardia
Phenylephrine Side Effects/ Precautions/ Comments
Capital:
Tachycardia, Hypertension, Increased myocardial oxygen demand, Dysrhythmia, Headache, Nausea/vomiting, Syncope
Incompatible with sodium bicarbonate
Infuse through a large, stable vein to avoid extravasation and tissue necrosis
Phenylephrine Adult Dose
CT Protocols:
Rapid Sequence Intubation
50 – 200 micrograms slow IV push every 2-5 minutes as needed for hypotension
Note: Assure appropriate volume resuscitation and other indicated treatments for hypotension.
Formulation:
Prefilled syringe or vial supplied as 50-100 micrograms/mL concentration that allows IV/IO administration without requiring dilution
Dave Thiery:
Put 10mg in 50ml bag = 200mcg/ml.
Phenylephrine Pediatric Dose
Capital:
0.01-0.5 mcg/kg/min IV/IO infusion
Phenylephrine
Max Dose Adult (Pediatric)
Capital:
Not recommended
Phenylephrine Routes of Administration
IV/IO
Phenylephrine How Supplied
Formulation:
Prefilled syringe or vial supplied as 50-100 micrograms/mL concentration that allows IV/IO administration without requiring dilution
