Diazepam Flashcards
Diazepam Trade Name?
Diazepam (Valium, Diastat ) (Not Carried by Nuvance)
Diazepam Classification?
Benzodiazepine
Diazepam Mechanism?
Capital/Medscape/Statpearls:
Binds to specific sites on GABA-A receptors to potentiate the effects of GABA by increasing the frequency at which the chloride channel opens, leading to hyperpolarization of the neuronal membrane and reduced neuronal excitability. Its inhibitory action in the amygdala is beneficial in anxiety disorders, while its inhibitory activity in the cerebral cortex is beneficial in seizure disorders.
Diazepam Indications?
CT Protocols:
Seizure, Sedation, Anxiolytic, Alcohol withdrawal, Post-intubation sedation
Diazepam Contraindications?
Capital: Hypersensitivity, Respiratory insufficiency, Hypotension
Diazepam Side Effects/Precautions?
Capital: Dizziness, Drowsiness, Confusion, Hypotension, Nausea/vomiting, Respiratory depression
Diazepam Adult Dose?
CT Protocols:
Alcohol Withdrawal, Restraints,
5-10mg IV/IO(preferred) or 5-10mg IM/IN; may repeat once in 5 minutes
Bradycardia/Transcutaneous Pacing, Seizure
5mg IV/IO, then 2.5mg every 5 mins to a total of 20mg
CPAP/BPAP, Hyperthermia, Tachycardia/Cardioversion, Traumatic Brain Injury
2mg IV/IO, may repeat once in 5 minutes
Nerve Agent
5mg IV/IO every 5 mins, or 10mg IM or Diazepam auto-injector (10mg; Repeat every 10 mins as needed
Poisoning/Substance Abuse/OD
2mg IV/IO, may repeat once in 5 minutes or
5mg IM, may repeat once in 20 minutes
Diazepam Pediatric Dose?
Capital: Seizures: 0.2 mg/kg – 0.5 mg/kg IV/IO/IM; max 10 mg/dose
Diazepam Onset of Action?
Capital: 1-5 minutes
Diazepam Duration of Action?
Medscape: 15-60 min (IV [sedative action])
Variable, dependent on dose and frequency (PO [hypnotic action]);
Diazepam Max Dose Adult/Pediatric?
20mg (10mg)
Diazepam Routes of Administration?
IV/IO/IM/PO
Diazepam How Supplied?
5mg/ml vials, ampules, and prefilled syringes
