Metoclopramide

Question 1

Metoclopramide Trade Name

Answer 1

Reglan (Not carried by Danbury)

Question 2

Metoclopramide Classification

Answer 2

CT Protocols:
Antiemetic

Question 3

Metoclopramide Mechanism

Answer 3

Medscape:
Blocks dopamine receptors (at high dose) and serotonin 5-HT3 receptors in chemoreceptor trigger zone of CNS; and sensitizes tissues to acetylcholine; increases upper GI motility but not secretions; increases lower esophageal sphincter tone

Question 4

Metoclopramide Onset of Action

Answer 4

Medscape:
1-3 min (IV, ); 10-15 min (IM); 30-60 min (PO)

Question 5

Metoclopramide Duration of Action

Answer 5

Medscape:
1-2 hr regardless of route

Question 6

Metoclopramide Indications

Answer 6

CT Protocols:
Nausea and/or vomiting (anti-emetic)
Migraine (diagnosed history and symptoms consistent with previous migraines)

Question 7

Metoclopramide Contraindications

Answer 7

Capital:
Hypersensitivity, Bowel obstruction, GI bleeding, History of seizure disorder, Parkinson’s Disease

Question 8

Metoclopramide Side Effects/ Precautions/ Comments

Answer 8

Capital:
Dystonia, Tardive dyskinesia, Dysrhythmia, Sedation, Irritability, Constipation, Diarrhea, Dry mouth, Hypertension, Hypotension

Question 9

Metoclopramide Adult Dose

Answer 9

CT Protocols:
Nausea/Vomiting
5 – 10 mg IV/IO/IM; May repeat once after 10 minutes if nausea/vomiting persists.
Pain Management - Migraine
10 mg IV/IO infusion over 15 minutes or 10 mg IM

Question 10

Metoclopramide Pediatric Dose

Answer 10

Not recommended

Question 11

Metoclopramide Max Dose Adult (Pediatric)

Answer 11

None noted

Question 12

Metoclopramide Routes of Administration

Answer 12

IV/IO/IM

Question 13

Metoclopramide How Supplied

Answer 13

5 mg/ml vials