Propofol

Question 1

Propofol Trade Name

Answer 1

Propofol (Diprivan)
(Not carried by Danbury)
(Not in CT Protocols)

Question 2

Propofol Classification

Answer 2

Medscape:
General Anesthetics, Systemic

Capital:
Sedative-Hypnotic

Question 3

Propofol Mechanism

Answer 3

Medscape:
Short-acting, lipophilic sedative/hypnotic; causes global CNS depression, presumably through agonist actions on GABAa receptors

Capital:
Works on multiple CNS receptor sites including GABA to cause rapid anesthesia

Question 4

Propofol Onset of Action

Answer 4

Capital: Immediate

Question 5

Propofol Duration of Action

Answer 5

Capital: Effects stop nearly immediately after infusion is discontinued

Question 6

Propofol Indications

Answer 6

Capital:
Anesthesia induction, Anesthesia maintenance, Sedation for mechanically ventilated patients

Question 7

Propofol Contraindications

Answer 7

Capital:
Hypovolemia, Hypersensitivity to drug, soybean oil, peanuts, or eggs.

Question 8

Propofol Side Effects/ Precautions/ Comments

Answer 8

Capital:
Hypotension, Seizure, Involuntary muscle movement, Nausea/vomiting, Dysrhythmia
Acute renal failure, Apnea

In pediatrics, Propofol can cause extreme bradycardia when administered with fentanyl

Avoid rapid administration in elderly due to high risk of hypotension

Question 9

Propofol Adult Dose

Answer 9

Capital:
Induction: 1.5-3.0 mg/kg IV/IO
Maintenance: 25-100 mcg/kg/min IV/IO infusion

Medscape: 2-2.5 mg/kg
0.1-0.2 mg/kg/min

Question 10

Propofol Pediatric Dose

Answer 10

Capital:
Induction: 2.5-3.5 mg/kg IV/IO
Maintenance: 125-300 mcg/kg/min IV/IO infusion

Question 11

Propofol
Max Dose Adult (Pediatric)

Question 12

Propofol Routes of Administration

Answer 12

IV/IO

Question 13

Propofol How Supplied

Answer 13

10mg/ml solution