Droperidol

Question 1

Droperidol Trade Name

Answer 1

Inapsine
(Not carried in Danbury)
(Not in CT Protocols)

Question 2

Droperidol Classification

Answer 2

Medscape:
Antiemetic Agent

Question 3

Droperidol Mechanism

Answer 3

Medscape:
Antiemesis: dopamine receptor blockade in brain, predominantly dopamine-2 receptor & when reuptake is prevented, a strong antidopaminergic, antiserotonic response occurs

Droperidol reduced motor activity, anxiety, and causes sedation; also possesses adrenergic-blocking, antifibrillatory, antihistaminic, & anticonvulsive properties

Question 4

Droperidol Onset of Action

Answer 4

Medscape:
3-10 minutes

Question 5

Droperidol Duration of Action

Answer 5

Medscape:
2-4 hrs

Question 6

Droperidol Indications

Answer 6

Medscape:
Droperidol has a central antiemetic action and effectively prevents postoperative nausea and vomiting in adults using doses as low as 0.625 mg.

For treatment of nausea and vomiting, droperidol and ondansetron are equally effective

Question 7

Droperidol Contraindications

Answer 7

Medscape:
Known or suspected QT prolongation (eg, QTc interval greater than 440 msec for males or 450 msec for females); including patients with congenital long QT syndrome

Question 8

Droperidol Side Effects/ Precautions/ Comments

Answer 8

Medscape:
Dysphoria, sedation, hypotension resulting from peripheral alpha adrenoceptor blockade, prolongation of QT interval which can lead to torsades de pointes, and extrapyramidal side effects such as dystonic reactions/neuroleptic malignant syndrome.

Cases of QT prolongation and/or torsades de pointes have been reported at doses at or below recommended doses. Some cases have occurred in patients with no known risk factors for QT prolongation and some cases have been fatal.

Question 9

Droperidol Adult Dose

Answer 9

Medscape:
Initial: No more than 2.5 mg IV/IM; additional doses of 1.25 mg may be given if benefit outweighs potential risk

Question 10

Droperidol Pediatric Dose

Answer 10

Medscape:
2-12 years: 0.03-0.07 mg/kg IV/IM over 2-5 minutes q4-6hr PRN
Not to exceed 0.1 mg/kg IV/IM, additional dose (no more than 2.5 mg) may be given ONLY IF benefit outweighs potential risk

Question 11

Droperidol Max Dose Adult (Pediatric)

Answer 11

??

Question 12

Droperidol Routes of Administration

Answer 12

IV/IO/IM

Question 13

Droperidol How Supplied

Answer 13

2.5mg/mL