Prochlorperazine Flashcards
Prochlorperazine Trade Name
Compazine
(Not carried by Danbury)
Prochlorperazine Classification
CT Protocols:
Antiemetic
Prochlorperazine Mechanism
Medscape:
Antiemetic: Antidopaminergic effect, blocking dopamine receptors in the brain, blocking vagus nerve in GI tract
Antipsychotic: Blocking mesolimbic dopamine receptors, and blocking alpha-adrenergic receptors (D1 and D2) in brain
Statpearls:
As a first-generation antipsychotic, prochlorperazine mainly blocks D2 dopamine receptors in the brain. It can also block histaminergic, cholinergic, and noradrenergic receptors.[1] One study found that prochlorperazine also inhibits the P2X7 receptor in human macrophages but not in mouse cells, preventing a calcium ion influx.[6] This mechanism was independent of dopamine antagonism.
Prochlorperazine Onset of Action
Medscape:
10-20 min (IM); 30-40 min (PO); 60 min (PR)
Prochlorperazine Duration of Action
Medscape:
3-4 hr (PO); 3-12hr (PR); extended-release, 10-12 hr
Prochlorperazine Indications
CT Protocols:
Nausea/vomiting
Migraines
Prochlorperazine Contraindications
Capital:
Hypersensitivity
Moderate risk for dystonic reaction – ensure availability of diphenhydramine
Use with caution with sedatives
Prochlorperazine Side Effects/ Precautions/ Comments
Capital:
Drowsiness, Blurred vision, Hypotension, Tachycardia, Dizziness
Prochlorperazine Adult Dose
CT Protocols
5-10 mg IV/IO/IM, May repeat once in 10 mins if N/V persists
Prochlorperazine Pediatric Dose
Not recomended
Prochlorperazine
Max Dose Adult (Pediatric)
None
Prochlorperazine Routes of Administration
IV/IO/IM
Prochlorperazine How Supplied
5mg/mL, 10mg/2ml
