Naloxone

Question 1

Naloxone Trade Name

Answer 1

Narcan

Question 2

Naloxone Classification

Answer 2

Capital:
Opioid antagonist, antidote

Question 3

Naloxone Mechanism

Answer 3

Capital:
Competitively binds to opiate receptors in the brain, displacing opiates and reversing effects of opiates

Question 4

Naloxone Onset of Action

Answer 4

Capital:
2 minutes

Question 5

Naloxone Duration of Action

Answer 5

Capital:
30-60 minutes

Question 6

Naloxone Indications

Answer 6

CT Protocols:
Opioid overdose with respiratory depression

Question 7

Naloxone Contraindications

Answer 7

CT Protocols:
Hypersensitivy
Neonate Age <1 month

Question 8

Naloxone Side Effects/ Precautions/ Comments

Answer 8

Capital:
- Seizures, Pulmonary edema, Tachycardia, Hypertension, Nausea/vomiting, Diaphoresis, Dysrhythmia, Cardiac arrest

• Increased respiratory depression when used with other CNS depressants
• Should be titrated to respiratory drive
• Caution when administering to patients with opiate dependency (risk of withdrawal, violent behavior)

Question 9

Naloxone Adult Dose

Answer 9

CT Protocols:

Pain Management
For iatrogenic opiate overdose, administer lowest dose to maintain oxygenation. If ventilation is effective, start with naloxone 0.04 mg IV/IO or ≤0.5 mg IM/IN. Titrate naloxone doses up to 2 mg (max total 10 mg) as needed.

Poisoning/Overdose/Substance Use Disorder
• 2 - 4 mg IN OR through the use of auto-injector.
• 0.04 - 2 mg IV/IO/IM
If no response, may repeat every 3 - 5 minutes to a total of 10 mg.

Question 10

Naloxone Pediatric Dose

Answer 10

Capital:
0.1 mg/kg IV/IO/IM/IN (max 2 mg/dose); repeat at 5-minute intervals as needed

Question 11

Naloxone Max Dose Adult (Pediatric)

Answer 11

10mg (2mg)

Question 12

Naloxone Routes of Administration

Answer 12

IV/IO/IM/IN

Question 13

Naloxone How Supplied

Answer 13

0.4mg/ml and 1mg/ml vials, ampules, and prefilled syringes