Cefazolin

Question 1

Cefazolin Trade Name

Answer 1

Ancef

Question 2

Cefazolin Classification

Answer 2

New Britain:
Antibiotic/ First-generation cephalosporin

Question 3

Cefazolin Mechanism

Answer 3

Medscape:
First-generation semisynthetic cephalosporin that binds to 1 or more penicillin-binding proteins, thereby arresting bacterial cell-wall synthesis and inhibiting bacterial replication; has poor capacity to cross blood-brain barrier; primarily active against skin flora, including S aureus

Question 4

Cefazolin Onset of Action

Answer 4

Medscape:
5 min (IV) (Immediate)
0.5-2 hr (IM)

Question 5

Cefazolin Duration of Action

Answer 5

Medscape:
Duration Unknown
Half-life: 90-150 min
Excretion: Urine (80-100% as unchanged drug)

Question 6

Cefazolin Indications

Answer 6

CT Protocols:
Open extremity fracture (indicated by visible bone)
Amputation proximal to the hand or foot
Major soft tissue injury

Question 7

Cefazolin Contraindications

Answer 7

CT Protocols:
Known penicillin or cefazolin allergy
Life threats not yet addressed
Patient contact duration too short

Question 8

Cefazolin Side Effects/ Precautions/ Comments

Answer 8

New Britain:
Seizure, abdominal cramps, diarrhea, nausea/vomiting, skin rash, pain at injection site
Must be reconstituted 1g in 10ml NS, exact time of administration must be documented.
Increased risk of bleeding with vitamin K agonists (warfarin)

Question 9

Cefazolin Adult Dose

Answer 9

CT Protocols:
Prophylaxis for Open Fracture or Major Open Wounds:
If > 39 kg, 2 grams IV/IO, slow…over 1-2 minutes
If < 39 kg, 50 mg/kg IV/IO slow…over 1-2 minutes;
round dose to nearest 100 mg

Question 10

Cefazolin Pediatric Dose

Answer 10

If < 39 kg, 50mg/kg IV/IO over 1-2 minutes

Question 11

Cefazolin Max Dose Adult (Pediatric)

Answer 11

2gm

Question 12

Cefazolin Routes of Administration

Answer 12

IV/IO/IM

Question 13

Cefazolin How Supplied

Answer 13

1gm vials (Danbury)