Diltiazem Flashcards
Diltiazem Trade Name
Cardizem
Diltiazem Classification
Medscape:
Antidysrhythmics, IV; Calcium Channel Blockers; Calcium Channel Blockers, Non-dihydropyridines
Capital:
Class IV antidysrhythmic; calcium channel blocker
Diltiazem Mechanism
Medscape:
Nondihydropyridine calcium-channel blocker: Inhibits extracellular calcium ion influx across membranes of myocardial cells and vascular smooth muscle cells, resulting in inhibition of cardiac and vascular smooth muscle contraction and thereby dilating main coronary and systemic arteries; no effect on serum calcium concentrations; substantial inhibitory effects on cardiac conduction system, acting principally at AV node, with some effects at sinus node
Capital:
Blocks calcium channels causing relaxation of vascular smooth muscle and slowing of conduction through the AV node.
Diltiazem Onset of Action
Capital:
2-5 Mins
Diltiazem Duration of Action
Capital:
1-3 hours
Diltiazem Indications
CT Protocols:
Calcium channel blocker used to treat narrow complex SVT
Capital:
Atrial fibrillation and atrial flutter with rapid ventricular response
SVT refractory to adenosine
Diltiazem Contraindications
CT Protocols:
Patients with heart block, ventricular tachycardia, WPW with atrial fibrillation, and/or acute MI.
Capital:
Hypotension, Sick sinus syndrome, High degree heart block, Bradycardia
Diltiazem Side Effects/ Precautions/ Comments
Capital:
AV blocks, Bradycardia, Hypotension, Chest pain, Syncope, VF/VT, CHF, Nausea/vomiting
Diltiazem Adult Dose
CT Protocols: Updated w 2023.1
Irregular tachycardia or regular tachycardia persisting after adenosine, consider:
10 mg IV/IO over at least 2 minutes. May repeat every 10 minutes, to a maximum total of 30 mg, to achieve a ventricular rate of <110.
Consider maintenance infusion at 5 – 15 mg/hour.
Diltiazem Pediatric Dose
Not Recommended
Diltiazem
Max Dose Adult (Pediatric)
20 mg
Diltiazem Routes of Administration
IV/IO
Diltiazem How Supplied
50mg/10ml (Expires 30 days)
