Flumazanil Flashcards
Flumazanil Trade Name
Romazicon
(Not carried in Danbury)
(Not in CT Protocols)
Flumazanil Classification
Capital:
Benzodiazepine antagonist
Flumazanil Mechanism
Capital:
Antagonizes the sedative effects of benzodiazepines in the CNS by inhibiting their actions on GABA
Flumazanil Onset of Action
Capital:
1-2 minutes
Flumazanil Duration of Action
Still not studying. But here’s what stat pearl says.
The onset of action is about 1 to 2 minutes; 80% response occurs within the first 3 minutes.The peak effect is 6 to 10 minutes after administration.The duration ranges from 19 minutes to 50 minutes, depending on the dose and benzodiazepine plasma concentrations.
Flumazanil Indications
Capital:
Respiratory depression and sedation associated with benzodiazepine overdose
Flumazanil Contraindications
Capital:
Hypersensitivity
Tricyclic antidepressant overdose
Seizure-prone patients
Benzodiazepine dependence
Flumazanil Side Effects/ Precautions/ Comments
Capital:
Seizures, Agitation, Confusion, Visual disturbances, Headache, Hypertension,
Nausea/vomiting, Tachycardia
Flumazanil Adult Dose
Capital:
1st dose: 0.2 mg IV/IO
If no effect from dose 1; 0.3 mg IV/IO
If no effect from dose 2; 0.5 mg IV/IO
If no effect, repeat 0.5 mg IV/IO until total of 3 mg is given
Flumazanil Pediatric Dose
Capital:
Not recommended
Flumazanil Max Dose Adult (Pediatric)
3mg
Flumazanil Routes of Administration
IV/IO
Flumazanil How Supplied
0.1 mg/ml vials
