Heparin

Question 1

Heparin Trade Name

Answer 1

No trade name
(Not carried by Danbury)
There are several heparin class drugs (fractions of unfractionated heparin) with lower molecular weight that have names like enoxaparin (Lovenox)

Question 2

Heparin Classification

Answer 2

Anticoagulants, Cardiovascular; Anticoagulants, Hematologic

Question 3

Heparin Mechanism

Answer 3

Medscape:
Mechanism for low dose: Inactivates factor Xa and inhibits conversion of prothrombin to thrombin
Mechanism for high dose: Inactivates factors IX, X, XI, and XII and thrombin and inhibits conversion of fibrinogen to fibrin
Also inhibits activation of factor VIII

Question 4

Heparin Onset of Action

Answer 4

Capital:
IV Immediate
SQ 20-60 minutes

Question 5

Heparin Duration of Action

Answer 5

Capital: 4-8 hours

Question 6

Heparin Indications

Answer 6

Capital:
Acute myocardial infarction
Prophylaxis and treatment of thromboembolic disorders (DVT, PE)

Question 7

Heparin Contraindications

Answer 7

Capital:
Hypersensitivity
Active bleeding
Recent intracranial, intra-spinal, or eye surgery
Severe hypertension

Question 8

Heparin Side Effects/ Precautions/ Comments

Answer 8

Capital:
Hemorrhage, Hematuria, GI bleeding, Shock, Pain, Bruising, Thrombocytopenia
Dose not lyse existing clots
Chance of bleeding increases when used in conjunction with other anticoagulants

Question 9

Heparin Adult Dose

Answer 9

Capital:
Bolus: 60 U/kg, max 4,000 U IV/SQ
Infusion: 12-15 U/kg/hr, max 1,000 U/hr

Question 10

Heparin Pediatric Dose

Answer 10

Not recommended

Question 11

Heparin Max Dose Adult (Pediatric)

Answer 11

4000 U

Question 12

Heparin Routes of Administration

Answer 12

IV/IO

Question 13

Heparin How Supplied

Answer 13

Capital:
25,000U/250ml premixed solutions (50 U/ml)