Norepinephrine Flashcards
Norepinephrine Trade Name
(Levarterenol, Levophed)
Norepinephrine Classification
Medscape:
Alpha/Beta Adrenergic Agonists, Sympathomimetic
Norepinephrine Mechanism
Medscape:
Strong beta1- and alpha-adrenergic effects and moderate beta2 effects, which increase cardiac output and heart rate, decrease renal perfusion and PVR, and cause variable BP effects
Capital:
Binds to Alpha 1, and Beta 1 adrenergic receptors with more profound Alpha 1 effects to cause peripheral vasoconstriction and coronary vasodilation
Norepinephrine Onset of Action
Capital: 1-3 minutes
Norepinephrine Duration of Action
Capital: Lasts 1 minute after discontinuation of infusion
Norepinephrine Indications
Capital:
Non-hypovolemic shock
CT Protocols:
Alpha 1 and Beta 1 receptor adrenergic receptor agonist vasopressor.
Norepinephrine Contraindications
Capital:
Hypovolemia, Tachydysrhythmia
Norepinephrine Side Effects/ Precautions/ Comments
Capital:
Tachycardia, Hypertension, Increased myocardial oxygen demand, Dysrhythmia, Headache, Nausea/vomiting, Syncope
Incompatible with sodium bicarbonate
Infuse through a large, stable vein to avoid extravasation and tissue necrosis
Norepinephrine Adult Dose
CT Protocols:
Post Resuscitation Care
- Infusion 1-30 microgram/minute titrated to effect must be given via pump or IV/IO flow regulating device.
Septic Shock
- Infusion 1-30 microgram/minute titrated to effect must be given via pump or IV/IO flow regulating device.
Norepinephrine Pediatric Dose
Capital:
0.01-0.5 mcg/kg/min IV/IO infusion
Norepinephrine
Max Dose Adult (Pediatric)
??
Norepinephrine Routes of Administration
IV/IO
Norepinephrine How Supplied
4mg vials
Mix 4mg in 250ml NS for a concentration of 16 mcg/ml
