Amiodarone

Question 1

Amiodarone Trade Name

Answer 1

Cordarone

Question 2

Amiodarone Classification

Answer 2

Medscape:
Class III Antidysrhythmic, Potassium Channel Blocker

Question 3

Amiodarone Mechanism

Answer 3

Potassium channel blocker that inhibits the efflux of potassium from the cell leading to a prolonged QT interval, prolonging the effective refractory period leading decreased myocyte excitability. Also, blocks beta-1 receptors and calcium and sodium channels leading to
decreased AV nodal conduction and SA node function

Question 4

Amiodarone Onset of Action

Answer 4

Capital:
Immediate

Question 5

Amiodarone Duration of Action

Answer 5

Capital:
30-45 Mins

Question 6

Amiodarone Indications

Answer 6

CT Protocols:
Antiarrhythmic used mainly in wide complex tachycardia and ventricular fibrillation.

Question 7

Amiodarone Contraindications

Answer 7

CT Protocols:
Avoid in patients with heart block or profound bradycardia.
Contraindicated in patients with iodine hypersensitivity.

Question 8

Amiodarone Side Effects/ Precautions/ Comments

Answer 8

Capital:
Prolonged QT Interval, Bradycardia, Heart block, Hypotension, CHF/pulmonary edema, Cough, Shortness of breath, Nausea, Dizziness, Burning at IV site.
Long half-life (46-58 days)

Question 9

Amiodarone Adult Dose

Answer 9

CT Protocols:
Cardiac Arrest
V-Fib/Pulseless V-Tach
300 mg IV/IO push. Repeat dose of 150 mg IV/IO push for recurrent episodes.
Tachycardia
Wide complex tachycardia
150 mg over 10 min. May repeat once in 10 minutes.
If successful, consider maintenance infusion of 1 mg/minute.

Question 10

Amiodarone Pediatric Dose

Answer 10

CT Protocols:
5 mg/kg (maximum 300 mg) IV/IO

Question 11

Amiodarone
Max Dose Adult (Pediatric)

Answer 11

Capital:
Do not exceed 2.2 grams per day

Question 12

Amiodarone Routes of Administration

Answer 12

IV/IO

Question 13

Amiodarone How Supplied

Answer 13

150mg/3ml vials or prefilled syringes