Mon jul 20

Question 1

inheritance of osler-weber-rendu syndrome?

Answer 1

autosomal dominant

Question 2

presentation of osler-weber-rendu syndrome?

Answer 2

skin and mucosal telangiectasies and reccurent nosebleeds. Mucosal involvment may involve lips, respiratory tract, GI tract and GU tract causing nose bleeds, hematuria and GI bleeds

Question 3

von recklinghousens disease AKA

Answer 3

NF1

Question 4

which portion of the duodenum becomes trapped in SMA syndrome?

Answer 4

the transverse portion

Question 5

Blastomycosis leads to granulomatous inflammation T or F?

Answer 5

TRUE

Question 6

what happens to the prostate when it is deprived of androgens?

Answer 6

atrophy, especially of the glandular components

Question 7

what is the rate limiting step of the pentose phosphate pathway?

Answer 7

glucose-6-phosphate to 6-phosphogluconate

Question 8

which enzyme converts glucose-6-phosphate to 6-phosphogluconolactone

Answer 8

glucose-6-phosphate dehydrogenase

Question 9

MOA of PCP (phenylcyclidine)

Answer 9

NMDA receptor antagonist, with lesser effects on reuptake of neurotransmitters

Question 10

pathogenesis of carbon tetrachloride poisoning?

Answer 10

forms free radicals in the liver following oxidation by the CYP450 system -> formation of CCl3 which causes lipid peroxidation

-> fatty change and hepatocyte necrosis

Question 11

formula for specificity?

Answer 11

TRUE NEG / (TRUE NEG + FALSE POS)

Question 12

formula for sensitivity?

Answer 12

TRUE POS / (TRUE POS + FALSE NEG)

Question 13

effects of dopamine at low doses?

Answer 13

activates D1 receptors in the renal vasculature and tubules –> increase in renal blood flow, GFR and Na excretion

Question 14

effects of dopamine at higher doses?

Answer 14

first begins to stimulate B1 - > increases CO. But at higher doses it also activates alpha-1 which increases vasoconstriction consequently decreasing CO