Friday July 3rd Flashcards
why arent adolescents able to weigh out risks and benefits of their behaviours as well as adults?
The prefrontal cortex doesnt complete development until the third decade of life
how is methicillin resistance (MRSA) usually mediated?
via changes in the penicillin binding proteins
are nafcillin, oxacillin and dicloxacillin sensitive or resistant to beta lactamases?
RESISTANT
where does the transcription of rRNA occur?
the nucleolus
which rna polymerase transcribes rRNA?
RNA polymerase I
which 2 neuropeptides may be decreased in a person with narcolepsy with cataplexy?
hypocretin-1 (orexin-1) and hypocretin-2 (orexin-2)
what is the function ohypocretin-1 (orexin-1) and hypocretin-2 (orexin-2)?
promote wakefullness and inhibit REM-sleep related phenomena
the mild form of leprosy (tuberculoid) is associated wiht which type of immune response?
Th1
the disseminated form of leprosy (lepromatous leprosy) is associated with which type of immune response?
Th2
how does the mild form of leprosy (tuberculoid) present?
small hypopigmented plaques with decreased sensation
how does the lepromin skin test differentiate between mild leprosy and lepromatous leprosy?
patients with the tuberculoid form (mild) develop a nodule at the site of injection due to a Th1 immune response, whereas patients who do not develop this nodule likely have a poor Th1 response and thus lepromatous leprosy
Glyburide is a ….
sulfonylurea
what type of drug is pioglitazone?
thiazolidinedione
thiazolidinedione MOA?
activate PPAR-gamma leading to increased insulin sensitivity and levels of adiponection
metformin MOA?
inhibits hepatic gluconeogenesis and the actions of glucagon -> increased glycolysis and peripheral glucose uptake
