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Test reviews DEDICATED > mon 24 > Flashcards

mon 24 Flashcards

1
Q

membranous nephropathy may be caused by antibodies to which substance?

A

phospholipase A2 receptor (expressed on podocytes)

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2
Q

what is the immunofluorescence pattern seen in membranous nephropathy?

A

granular due to immune complex deposition

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3
Q

what is the EM pattern seen on membranous nephropathy?

A

spike and dome

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4
Q

what causes the mesangial expainsion in diabetic glomerulonephropathy?

A

nonenzymatic glycation of tissue proteins

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5
Q

diffuse proliferative glomerulonephritis is often due to which disease?

A

SLE

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6
Q

what will b seen on LM or diffuse proliferative glomerulonephritis?

A

wire looping

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7
Q

inheritance of alport syndrome?

A

x linked

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8
Q

type II membranoproliferative glomerulonephritis will have which igG autoantibody?

A

C3 nephritic factor - stabilizes C3 convertase

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9
Q

why does imatinib help treat GIST?

A

it ALSO blocks c-kit tyrosine kinase

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10
Q

what does erlotinib block?

A

EGFR

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11
Q

erlotinib A/E?

A

diarrhea and acneiform rash

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12
Q

what do sunitinib and sorafenib inhibit?

A

VEGFR overexpresison

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13
Q

what does vemurafenib inhibit?

A

B-raf (BRAF)

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14
Q

what cancer commonly has a V600E BRAF mutation?

A

malignant melanoma

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15
Q

what does bevacuzimab target?

A

VEGF

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16
Q

what kind of drugs are carmustine and lomustine?

A

nitrosureas

17
Q

how does valproic acid affect weight?

A

weight gain

18
Q

how does topiramate affect weight?

A

weight loss

19
Q

side effects of lamotrigine?

A

diplopia, SJS

20
Q

which antiseizure drug is associated with gingival hypertrophy?

A

phenytoin

21
Q

which antiseizure drug is associated with hirsutism?

A

phenytoin

22
Q

which antiseizure drug is associated with SIADH?

A

carbamazepine

23
Q

gabapentin MOA?

A

blocks Ca channels

24
Q

MOA of ethosuxamide?

A

blocks T type Ca channels in thalamus

25
Q

which seizure drug may cause acute closed angle glaucoma?

A

topiramate

26
Q

carbamazepine MOA?

A

increases Na channel inactivation

27
Q

A/E of carbemapazine?

A
  • SIADH
  • agranulocytosis
  • DRESS syndrome
  • SJS
28
Q

phenytoin MOA?

A

increases Na channel inactivation

29
Q

effects of phenytoin and carbamazepine on CYP 450s?

A

inducers

30
Q

gabapentin MOA

A

blocks voltage gated Ca channels

31
Q

what is primidone?

A

barbituate

32
Q

effects of V1 activation?

A

vasoconstrictino

33
Q

what type of receptor is V1?

A

Gq

34
Q

what type of receptor is V2?

A

Gs

35
Q

where are V2 receptors found?

A

the collecting duct

36
Q

how does administering desmopressin help treat esophageal varicies?

A

it causes vasoconstriction -> reduced bleeding

37
Q

MOA of the ‘vaptan’ drugs?

A

BLOCK V2 receptors- treat SIADH

38
Q

demeclocycline use?

A

treats SIADH

Test reviews DEDICATED (70 decks)

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