BMS10-1030 Pharmacology & the Cardiovascular System Flashcards
Perfusion pressure
Difference in pressure between arteries and veins
Which is the main regulator of this?
Sympathetic nervous system
What does the baroreceptor response alter? (3)
Cardiac, vascular and renal function
What may cause postural hypotension?
Side effect of drugs that block the SNS
Why do we get venous pooling?
The veins are more elastic
What 3 variables must you consider before giving drugs?
Arterial blood pressure
Peripheral resistance
Heart rate
What can changes in diastolic BP indicate?
Changes in peripheral resistance; it is the main factor as valves are closed in diastole so the heart isn’t pumping blood into arteries
What can changes in systolic BP indicate?
Peripheral resistance and cardiac out put as in systole blood is being pumped out into arteries so increasing both of these increases BP
What does noradrenaline (alpha agonist) do?
Constrict smooth muscles increases resistance and therefore BP so we begin bradycardia
What does isoprenaline (beta agonist do)
Relax smooth muscle so heart rate and force increases decreasing resistance but increasing CO so MABP decreases
What does adrenaline (beta and alpha agonist) do?
Mainly constrict to increase rate and force to reduce resistance and increase CO to increase mean BP
What will a B2 isoprnaline do?
Relax smooth muscle to decrease resistance
What do B1 and baroreceptors do?
Increase HR and force to increase CO
What are some affects of alpha agonists?
Relax gut
Dilate pupils
Glycogen mobilsation
What are some affects of beta agonists?
Relax bronchial
Relax gut
Glycogen and fat mobilisation
