BMS07-1025 Metabolism Overview

Question 1

Metabolism

Answer 1

Totality of chemical reaction and physical changes that occur in living organisms

Question 2

Catabolism

Answer 2

Breaking down

Question 3

Anabolic

Answer 3

Building up

Question 4

Lysis

Answer 4

Breaking down

Question 5

Genesis

Answer 5

Building up

Question 6

Why are metabolic pathways complicated?

Answer 6

To release lots of small packets of useable energy rather than one large amount

Question 7

How do we use enzymes to avoid a futile cycle?

Answer 7

Different enzymes are used to speed up the forwards and backwards pathway

Question 8

What stores energy?

Answer 8

Activated carrier molecules

Question 9

High energy carried group of ATP, NADH etc, acetyl coA and UDP

Answer 9

Pi
e and H
Acetyl
Glucose

Question 10

At what pH is ATP stable?

Answer 10

Ph 6-9

Question 11

Which AA make up ATP?

Answer 11

Adenine

Ribose

Question 12

Why does ATP want to break down?

Answer 12

Pi groups have electrostatic repulsion so entropy increases as it’s more stable

Question 13

Comapre ATP to AMP + PPi with ATP to ADP

Answer 13

Making AMP releases nearly twice as much energy

Question 14

What turns on protein kinase?

Answer 14

Taking a Pi from ATP

Question 15

How is glucose-6-phosphate formed?

Answer 15

Glucose + ATP

Question 16

UTP synthesises…

Answer 16

Complex sugars

Question 17

GTP synthesises…

Answer 17

Proteins

Question 18

What replaces NAD in which reaction? Give an example

Answer 18

NADP in anabolic reactions such as lipid synthesis

Question 19

FAD goes to…

Answer 19

FADH2

Question 20

Coenzyme A forms which bond with which chemical?

Answer 20

Thioester linkages with COOH

Question 21

How are AA respired?

Answer 21

Transamination

Question 22

How are FA respired?

Answer 22

Beta oxidation

Question 23

How does glycolysis form the 2C acetyl unit?

Answer 23

Pyruvate

Question 24

What molecule do all metabolism pathways make for the citric acid cycle?

Answer 24

Acetyl 2C units

Question 25

Draw pyruvate

Answer 25

https://www.bing.com/images/search?view=detailV2&id=1DDC4970C0DDCBEEBC16D87548FFFBC7834A550B&thid=OIP.rRQUde8yjXErL-J5mg2NRAHaDt&mediaurl=http%3A%2F%2Foregonstate.edu%2Finstruct%2Fbb450%2F450material%2Fstryer7%2F16%2Funnumbered_16_p468.jpg&exph=702&expw=1400&q=pyruvate&selectedindex=5&ajaxhist=0&vt=0&eim=1,6

Question 26

Which energy fuel is metabolised in the cytoplasm?

Answer 26

Glucose

Question 27

What fuels enter the mitochondria?

Answer 27

FA and pyruvate, therefore acetyl coenzymeA

Question 28

How is pyruvate used anaerobically?

Answer 28

NADH + H = NAD
Lactate dehydrogenase
Lactate

Question 29

Draw lactate

Answer 29

https://www.bing.com/images/search?view=detailV2&id=1DDC4970C0DDCBEEBC16D87548FFFBC7834A550B&thid=OIP.rRQUde8yjXErL-J5mg2NRAHaDt&mediaurl=http%3A%2F%2Foregonstate.edu%2Finstruct%2Fbb450%2F450material%2Fstryer7%2F16%2Funnumbered_16_p468.jpg&exph=702&expw=1400&q=pyruvate&selectedindex=5&ajaxhist=0&vt=0&eim=1,6

Question 30

Draw acetyl coenzyme A

Answer 30

https://www.bing.com/images/search?view=detailV2&id=CD8F3C643D2F8B64F1FA35D9C2A3865BA22DA178&thid=OIP.GyulVldRRD9b_BeHaiQ2_gHaDc&mediaurl=http%3A%2F%2Fupload.wikimedia.org%2Fwikipedia%2Fcommons%2Fthumb%2F8%2F89%2FAcetyl-CoA.svg%2F1280px-Acetyl-CoA.svg.png&exph=596&expw=1280&q=acetyl+coenzyme+A+structure&selectedindex=1&ajaxhist=0&vt=0&eim=1,6