VIN Flashcards
What is vulval intraepithelial neoplasia (VIN)?
Vulval intraepithelial neoplasia (VIN) is a pre-cancerous skin lesion of the vulva.
What can VIN result in if untreated?
VIN may result in squamous skin cancer if untreated.
What is the average age of a woman affected by VIN?
The average age of a woman affected by VIN is around 50 years.
What are the risk factors for VIN?
Risk factors for VIN include human papilloma virus (HPV) 16 & 18, smoking, herpes simplex virus 2, and lichen sclerosus.
What are the common features of VIN?
Common features of VIN include itching, burning, and raised, well-defined skin lesions.
How is VIN investigated?
VIN is investigated through biopsy (punch biopsy or excisional biopsy) for histological diagnosis and HPV testing (PCR or in situ hybridisation) for high-risk HPV DNA.
What topical therapies are used for VIN?
Topical therapies used for VIN include imiquimod and 5-Fluorouracil.
What is imiquimod and how is it used in VIN management?
Imiquimod is an immune response modifier used as a topical therapy for VIN.
What is 5-Fluorouracil and how is it used in VIN management?
5-Fluorouracil is a topical chemotherapeutic agent used in VIN management.
What are the goals of surgical interventions for VIN?
The goals of surgical interventions for VIN are to completely remove dysplastic areas while preserving normal anatomy and function as much as possible.
What surgical techniques are used for VIN management?
Surgical techniques for VIN management include wide local excision, laser ablation, and more radical approaches like partial vulvectomy in cases of extensive disease.
What is the follow-up and surveillance protocol for VIN?
Follow-up and surveillance for VIN involve regular monitoring with repeat colposcopy and biopsy if recurrence or progression is suspected.
