Pregnancy_Jaundice_Flashcards
What is intrahepatic cholestasis of pregnancy (ICP)?
Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, is a liver disorder that occurs during pregnancy.
How common is intrahepatic cholestasis of pregnancy?
Intrahepatic cholestasis of pregnancy occurs in around 1% of pregnancies.
When is intrahepatic cholestasis of pregnancy generally seen?
Intrahepatic cholestasis of pregnancy is generally seen in the third trimester.
What are the features of intrahepatic cholestasis of pregnancy?
Features of intrahepatic cholestasis of pregnancy include pruritus (often in the palms and soles), no rash, and raised bilirubin.
What is a notable feature of intrahepatic cholestasis of pregnancy regarding skin changes?
In intrahepatic cholestasis of pregnancy, there is no rash, although skin changes may be seen due to scratching.
What is typically raised in intrahepatic cholestasis of pregnancy?
Bilirubin is typically raised in intrahepatic cholestasis of pregnancy.
How is intrahepatic cholestasis of pregnancy managed?
Management of intrahepatic cholestasis of pregnancy includes ursodeoxycholic acid for symptomatic relief, weekly liver function tests, and typically inducing women at 37 weeks.
What complications are associated with intrahepatic cholestasis of pregnancy?
Complications of intrahepatic cholestasis of pregnancy include an increased rate of stillbirth. It is not generally associated with increased maternal morbidity.
What is acute fatty liver of pregnancy?
Acute fatty liver of pregnancy is a rare complication that may occur in the third trimester or the period immediately following delivery.
When may acute fatty liver of pregnancy occur?
Acute fatty liver of pregnancy may occur in the third trimester or the period immediately following delivery.
What are the features of acute fatty liver of pregnancy?
Features of acute fatty liver of pregnancy include abdominal pain, nausea and vomiting, headache, jaundice, hypoglycaemia, and severe disease may result in pre-eclampsia.
What investigations are indicative of acute fatty liver of pregnancy?
Elevated ALT (e.g., 500 u/l) is indicative of acute fatty liver of pregnancy.
How is acute fatty liver of pregnancy managed?
Management of acute fatty liver of pregnancy involves supportive care and once stabilized, delivery is the definitive management.
Which syndromes may be exacerbated during pregnancy?
Gilbert’s syndrome and Dubin-Johnson syndrome may be exacerbated during pregnancy.
What does HELLP stand for in the context of pregnancy-related jaundice?
HELLP stands for Haemolysis, Elevated Liver enzymes, Low Platelets.