EPILEPSY BREASTFEEDING Flashcards
What is the general recommendation for women with epilepsy considering pregnancy regarding folic acid?
All women thinking about becoming pregnant should be advised to take folic acid 5mg per day well before pregnancy to minimise the risk of neural tube defects.
What is the risk of congenital defects in newborns of non-epileptic mothers compared to those taking antiepileptic medication?
Around 1-2% of newborns born to non-epileptic mothers have congenital defects, which rises to 3-4% if the mother takes antiepileptic medication.
What is the aim of antiepileptic therapy during pregnancy?
The aim is to use monotherapy for antiepileptic therapy during pregnancy.
Is there a need to monitor antiepileptic drug levels during pregnancy?
There is no indication to monitor antiepileptic drug levels during pregnancy.
What are the risks associated with sodium valproate during pregnancy?
Sodium valproate is associated with neural tube defects and a significant risk of neurodevelopmental delay in children.
Which antiepileptic is often considered the least teratogenic of the older medications?
Carbamazepine is often considered the least teratogenic of the older antiepileptics.
What congenital defect is associated with phenytoin use during pregnancy?
Phenytoin use during pregnancy is associated with cleft palate.
What are the considerations for lamotrigine use during pregnancy?
Studies suggest the rate of congenital malformations with lamotrigine may be low, but the dose may need to be increased during pregnancy.
Is breastfeeding considered safe for mothers taking antiepileptics?
Breastfeeding is generally considered safe for mothers taking antiepileptics, with the possible exception of the barbiturates.
What is the recommendation for pregnant women taking phenytoin in the last month of pregnancy?
It is advised that pregnant women taking phenytoin are given vitamin K in the last month of pregnancy to prevent clotting disorders in the newborn.
What did the November 2013 Drug Safety Update warn about regarding sodium valproate use during pregnancy?
The update warned about a significant risk of neurodevelopmental delay in children following maternal use of sodium valproate.
What is the recommendation for sodium valproate use in women of childbearing age?
Sodium valproate should not be used during pregnancy and in women of childbearing age unless clearly necessary, and women of childbearing age should not start treatment without specialist neurological or psychiatric advice.
